A novel somatostatin receptor ligand for human ACTH – and GH –secreting pituitary adenomas
Daniela Regazzo,
Serena Avallone,
Cliona P MacSweeney
et al.
Abstract:Somatostatin receptor ligands have come to play a pivotal role in the treatment of both ACTH- and GH-secreting pituitary adenomas. Clinical efficacy averages 30-50%, thus a considerable number of patients with Cushing’s disease or acromegaly remain unresponsive to this therapeutic approach. HTL0030310 is a new somatostatin receptor ligand selective for subtype 5 over subtype 2, thus with a different receptor profile compared to clinical somatostatin receptor ligands. The aim of the present study was to evaluat… Show more
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