A novel soluble β-1,3-<scp>d</scp>-glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice

Zhang, Ying; Xia, Lin; Pang, Wenqiang; Wang, Tao; Chen, Peng; Zhu, Bin; Zhang, Jianfa

doi:10.1017/s0007114512000980

Cited by 44 publications

(19 citation statements)

References 51 publications

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“…These properties suggested that Salecan could be utilized in the food industry as a new source of thickening agent and medical industry for preventing and treating constipation. [29][30][31][32][33][34] In addition, Salecan affords a high density of hydroxyl groups, which can be modied to provide greater exibility in the preparation of hydrogels. Recently, Salecan-based hydrogels were successfully fabricated in our laboratory.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

Wei

et al. 2015

J. Mater. Chem. B

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125

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Salecan is a novel water-soluble extracellular b-glucan produced by a salt-tolerant strain Agrobacterium sp.ZX09. Salecan is suitable for the fabrication of hydrogels for biomedical applications due to its excellent physicochemical and biological properties. In this paper, a series of pH-sensitive hydrogels were prepared in aqueous solution by the graft copolymerization of Salecan and acrylic acid (AA) using N,N 0 -methylene diacrylamide as a crosslinker for controlled drug delivery. The structure and thermal stability of the resulting hydrogels were characterized by FT-IR, XRD and TGA. By SEM analysis, freeze-dried hydrogels displayed an interconnected porous structure with tunable pore size in the range of 23.2-90.3 mm. The swelling behavior of the hydrogels was shown to be highly dependent on the environmental pH, salt type and concentration, as well as the contents of Salecan and BAAm. They are almost unswellable at pH 1.2 and swollen extensively at pH 6.86. Meanwhile, the increase in the content of hydrophilic Salecan could enhance the swelling ratio, whereas the presence of more BAAm reduced the swelling capacity but promoted the water retention to some extent. Rheological tests revealed that storage modulus G 0 was strongly influenced by the crosslink density of the obtained hydrogel network.Especially, doxorubicin (DOX) as a model anti-cancer drug was very efficiently loaded into the negatively charged hydrogels (up to 69.4 wt%) through electrostatic interactions. More importantly, the release of DOX from this intelligent system exhibited pH-responsive behavior and a sustained release pattern. For SPA2, the cumulative release profile showed a low level of drug release (about 12.3 wt% in 24 h) at pH 7.4, and was significantly accelerated at pH 4.0 (over 40 wt% in 6 h). Cytotoxicity experiments confirmed that all blank hydrogels were non-toxic to A549 cells, while DOX released from the drug-loaded hydrogels remained biologically active and had the capability to kill cancer cells. The preliminary results clearly suggested that the Salecan-g-PAA hydrogels may be promising carriers for controlled drug delivery.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

Wei

et al. 2015

J. Mater. Chem. B

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125

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“…The structure of salecan is a linear (1→3)-␤-d-glucan consisted of ␤-1-3-linked glucopyranosyls with a small quantity of ␣-1-3-linked [33]. As a novel polysaccharide, salecan has been utilized in the fields of both food and medical in our laboratory [34][35][36][37][38]. With a high density of hydroxyl groups, the large molecular weighted (2 × 10 6 Da) salecan could be further modified for multifarious applications.…”

Section: Introductionmentioning

confidence: 99%

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Wei

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…The method of beta‐glucan preparation was previously described (Zhang et al, ). Briefly, Agrobacterium sp.…”

Section: Methodsmentioning

confidence: 99%

Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets

Luo

Liu

et al. 2019

Animal Physiology Nutrition

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Beta‐glucan is currently under consideration as an alternative to in‐feed antibiotics. The aim of the study was to investigate Agrobacterium sp. ZX09 beta‐glucan on intestinal morphology, cytokine concentration, mucin expression and microbial populations of weaning piglets. Pigs were randomly assigned to one of five dietary treatments supplemented with 0, 25, 50, 100 and 200 mg/kg beta‐glucan. Data showed an increase in ADG at the 100 mg/kg group (p = .03). A significant increase in villus height and reduction in crypt depth were fund in ileal tissue at the 100 mg/kg inclusion level (p < .05). Dietary supplementation of 100 mg/kg beta‐glucan enhanced IL‐10 concentration (p = .04) and gene expression of MUC1 and MUC2 (p < .05) in the jejunum. Dietary supplementation of 100 mg/kg beta‐glucan provoked the up‐regulation of Lactobacillus counts and down‐regulation of Escherichia coli counts in the caecum (p = .05). Data suggested that improved growth performance in response to beta‐glucan supplementation at 100 mg/kg in weaned piglets may be explained by the improved intestinal function.

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A novel soluble β-1,3-d-glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice

Cited by 44 publications

References 51 publications

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Beta‐glucan from Agrobacterium sp. ZX09 improves growth performance and intestinal function in weaned piglets

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