A novel soluble lornoxicam-sodium chelate monohydrate with improved plasticity and tabletability

Chen, Hui; Zhang, Jingwen; Qiao, Qiyang; Hu, Enshi; Wei, Yuanfeng; Pang, Zunting; Gao, Yuan; Qian, Shuai; Zhang, Jianjun; Heng, Weili

doi:10.1016/j.ijpharm.2022.122060

Cited by 5 publications

(1 citation statement)

References 71 publications

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“…Nanoparticles exhibited higher saturation solubility as compared to bulk particles which can be described by the Ostwald-Freundlich equation [3]. Several particle engineering based approaches such as solid-lipid particles, nanocrystals and nano-emulsion have been explored recently to enhance the dissolution rate of lornoxicam [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Solubility Prediction of Lornoxicam in Different Pure Solvents Using Semi-Empirical Correlations and Thermodynamic Models

Kumar

Thakur²,

KULABHİ³

et al. 2023

International Journal of Thermodynamics

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The solubility data of Active Pharmaceutical Ingredients in organic solvents is an essential for pharmaceutical crystallization and drug formulation. In this work, two semi-empirical correlations- the Yaws model and λ-h model- and two thermodynamic models – Wilson Model and the Non-random two-liquid model- are used to estimate the solubility of lornoxicam in ethanol and water. The model parameters and correlations coefficients are calculated by optimizing the average relative deviation. The values of these parameters will be helpful to estimate the solubility of lornoxicam at different temperatures where the experimental solubility data is not available. The predicted solubility data of lornoxicam can be further utilized in the pharmaceutical crystallization and drug formulation.

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