A novel sol–gel-material prepared by a surface imprinting technique for the selective solid-phase extraction of bisphenol A

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

“…They are often misleading and certainly unsuitable for being used in systematic method design. It can happen for instance, that the IF is high, but the difference between the MIP and the NIP is small in the practical application [41]. Note that the difficulty of adequately defining selectivity is generally observed in analytical chemistry [42,43].…”

Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

“…2,3 Recently, MIPs, as highly selective solid adsorbents, have been widely used in various fields, such as separation and preconcentration, manufacturing of sensors, the stationary phases for chromatography, pseudo immunoassay, catalysis and others. [2][3][4][5][6][7][8][9] In particular, new method of molecularly imprinted solid phase extraction (SPE), in which the MIP-solid adsorbent can selectively extract, has attracted much attention in the separation and enrichment area. 6,[10][11][12] The usual method for preparing MIPs, the entrapping way, has some disadvantages, such as time-consuming and complicated preparation method, less recognition sites within the matrix polymer particles obtained by crushing and grinding imprinted polymeric monolith, and greater diffuse barrier for the template molecules coming from matrix thickness, resulting in poor binding capacity and lower binding kinetics of MIPs to the template molecule.…”

“…[2][3][4][5][6][7][8][9] In particular, new method of molecularly imprinted solid phase extraction (SPE), in which the MIP-solid adsorbent can selectively extract, has attracted much attention in the separation and enrichment area. 6,[10][11][12] The usual method for preparing MIPs, the entrapping way, has some disadvantages, such as time-consuming and complicated preparation method, less recognition sites within the matrix polymer particles obtained by crushing and grinding imprinted polymeric monolith, and greater diffuse barrier for the template molecules coming from matrix thickness, resulting in poor binding capacity and lower binding kinetics of MIPs to the template molecule. 13,14 In order to overcome these disadvantages, the method of surface-imprinting was developed and put toward as a new molecular imprinting technique: 2,3,6,15 (i) pre-grafting of functional polymers in the form of a thin layer (in the manner of ''grafting from'' or ''grafting to'') on the surface of silica gel particles; (ii) adsorption of the template molecule towards grafted particle is saturated by the intermolecular interactions; (iii) post-imprinting of template molecule is associated with the use of specific cross-linking agent that has two reactive end groups.…”

“…6,[10][11][12] The usual method for preparing MIPs, the entrapping way, has some disadvantages, such as time-consuming and complicated preparation method, less recognition sites within the matrix polymer particles obtained by crushing and grinding imprinted polymeric monolith, and greater diffuse barrier for the template molecules coming from matrix thickness, resulting in poor binding capacity and lower binding kinetics of MIPs to the template molecule. 13,14 In order to overcome these disadvantages, the method of surface-imprinting was developed and put toward as a new molecular imprinting technique: 2,3,6,15 (i) pre-grafting of functional polymers in the form of a thin layer (in the manner of ''grafting from'' or ''grafting to'') on the surface of silica gel particles; (ii) adsorption of the template molecule towards grafted particle is saturated by the intermolecular interactions; (iii) post-imprinting of template molecule is associated with the use of specific cross-linking agent that has two reactive end groups. After removal of the template molecule, a mass of the imprinted caves able to recognize and re-bind the template molecules is left and distributed in the thin polymer layer, resulting in imprinted material with high performance such as more accessible sites, fast mass transfer and high recognition and binding ability to template molecule.…”

Protein binding to peptide-imprinted porous silica scaffolds

“…Inorganic materials, however, offer advantages. For example, amorphous polysiloxane (silica) formed by sol-gel processing can provide high selectivity, high level of accessible binding sites, and faster mass transfer and binding [13].…”