A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows

Liu, Yanxin; Li, Daqi; Li, Huixia; Zhou, Xuan; Wang, Genlin

doi:10.1007/s11033-010-0080-8

Cited by 80 publications

(81 citation statements)

References 31 publications

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“…A number of researches in genome-wide SNP genotyping has been progressively achieved, such as cost-effective dairy cattle breeding programs (Hayes et al2009), useful information on genetic variation of Korean Hanwoo breed (Dadi et al 2012) and indicine and African cattle breeds (Matukumalli et al 2009), and genome wide association for milk production in Danish Jersey cattle (May et al 2010). Specific SNPs associated with genes have also been elucidated their association with targeted traits in dairy and beef cattle (Liu et al 2011;Lu et al 2011;Deb et al 2014). Thus, our study is relevant with previous studies using Bovine SNP array conducted in many countries to offer a useful knowledge and promise for improving targeted traits in cattle.…”

Section: Gucy2cplbd1supporting

confidence: 54%

Identification of Single Nucleotide Polymorphisms on Cattle Breeds in Indonesia Using Bovine 50k

Lestari

Rijzaani

Satyawan

et al. 2016

Indones. J. Agric. Sci.

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Single nucleotide polymorphisms (SNPs) abundant in bovine genome influence genetic variation in biological mechanism. The study aimed to identify SNPs on Indonesian cattle breeds and analyze their genetic diversity using Bovine 50K SNP chip. Twenty eight "Ongole Grade" (OG) beef cattle and 20 "Holstein Friesian" (HF) dairy cattle were used for the Infinium II assay test. This assay included amplification of genomic DNA, fragmentation, precipitation, resuspension, hybridization, processing bead chip for single-base extension, and imaging at iScan. Data and clusters were analyzed using GenomeStudio software. The Bovine 50K SNP chip containing 54,609 SNPs was observed spanning all chromosomes of bovine genome. Genotyping for the total SNPs was successfull based on Call Rate, GeneCall and GeneTrain scores. Most SNP markers had alleles that shared among the individuals or breeds, or had specific alleles at distinctive frequencies. Minor allele frequency (MAF) spreads equally with intervals of 0-0.5. The breeds of OG and HF tended to be separated in different clusters without considering their genetic history and twin or normal. This result suggests that most individuals are closely related to one another, regardless of the same breed. Some genes identified on chromosomes 3, 4, 5, 7, 13, 17 and 18 were located in the loci/regions that contained SNPs with specific alleles of either HF or OG breed. These SNPs were more powerful for differentiation of beef cattle and dairy cattle than among individuals in the same breed. These SNP variations and genetic relatedness among individuals and breeds serve basic information for cattle breeding in Indonesia.[ 3, 4, 5, 7, 13, 17, dan

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Section: Gucy2cplbd1supporting

confidence: 54%

Identification of Single Nucleotide Polymorphisms on Cattle Breeds in Indonesia Using Bovine 50k

Lestari

Rijzaani

Satyawan

et al. 2016

Indones. J. Agric. Sci.

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“…7). Though the activation of HSPs in response to heat stress is very well characterized, polymorphism in these genes could be associated with milk yield in lactating cattle Liu et al 2011); moreover, the expression of these genes could also be verified for their effect on milk yield in lactating cows in the hot season.…”

Section: Heat Stress Resulted In the Activation Of Heat Shock Factorsmentioning

confidence: 99%

Characterization of genes and pathways that respond to heat stress in Holstein calves through transcriptome analysis

Srikanth

Kwon

Lee

2017

Cell Stress and Chaperones

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This study aimed to investigate the genes and pathways that respond to heat stress in Holstein bull calves exposed to severe ranges of temperature and humidity. A total of ten animals from 4 to 6 months of age were subjected to heat stress at 37°C and 90 % humidity for 12 h. Skin and rectal temperatures were measured before and after heat stress; while no correlation was found between them before heat stress, a moderate correlation was detected after heat stress, confirming rectal temperature to be a better barometer for monitoring heat stress. RNAseq analysis identified 8567 genes to be differentially regulated, out of which 465 genes were significantly upregulated (≥2-fold, P < 0.05) and 49 genes were significantly downregulated (≤2-fold, P < 0.05) in response to heat stress. Significant terms and pathways enriched in response to heat stress included chaperones, cochaperones, cellular response to heat stress, phosphorylation, kinase activation, immune response, apoptosis, Toll-like receptor signaling pathway, Pi3K/AKT activation, protein processing in endoplasmic reticulum, interferon signaling, pathways in cancer, estrogen signaling pathway, and MAPK signaling pathway. The differentially expressed genes were validated by quantitative realtime PCR analysis, which confirmed the tendency of the expression. The genes and pathways identified in this analysis extend our understanding of transcriptional response to heat stress and their likely functioning in adapting the animal to hyperthermic stress. The identified genes could be used as candidate genes for association studies to select and breed animals with improved heat tolerance.

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“…Chen et al (2013) indicated that SNP C.-141G>A in the 5'-flanking region of the Hsp90b gene in chickens had some effect on thermotolerance traits, and this might be a potential molecular marker of thermotolerance. Liu et al (2011) found that a novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows. In this study, 10 SNPs were identified in a 2400-bp 5'-flanking region of the chicken GRP78 gene, and seven of these polymorphism sites caused transcription factor binding sites to disappear, occur, or change.…”

Section: Discussionmentioning

confidence: 98%

Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression

Kong¹,

Zhang²,

Ji³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Glucose-regulated protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum and can be induced by different kinds of environmental and physiological stress. Thus far, the role of the GRP78 gene in thermotolerance in chickens has not been investigated. In the present study, we detected sequence variations in the 5ꞌ-flanking region of the GRP78 gene and evaluated several thermotolerance parameters, such as T3, corticosterone, H/L ratio, and levels of CD3 + , CD4 + , and CD8 + T cells, to further determine its associations at 35° and 15°C. The sequencing results revealed 10 SNPs in the 5'-flanking region of the GRP78 gene, and seven mutations were chosen for further genotyping in a White Recessive Rock (WRR) chicken population. The SNP C.-744C>G in WRR chickens was significantly correlated with heat tolerance parameters under both conditions; it may therefore exert 6111 Chicken GRP78 gene expression and thermotolerance ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6110-6123 (2015) a potential hereditary effect on heat tolerance, and the genotype GG may be advantageous for thermotolerance. The heart, liver, brain, and leg muscle tissues of 8-day-old WRR chickens were sampled from heat stress groups, which were defined by exposure to 1, 2, 3, and 6 h of persistent thermal stress, and a control group, which was not exposed to thermal stress. Quantitative real-time polymerase chain reaction assay indicated that the mRNA expression level of the GRP78 gene increased gradually under heat stress, peaked at 3 h, and then decreased. We conclude that the mRNA expression of the GRP78 gene is time-and tissue-dependent.

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A novel SNP of the ATP1A1 gene is associated with heat tolerance traits in dairy cows

Cited by 80 publications

References 31 publications

Identification of Single Nucleotide Polymorphisms on Cattle Breeds in Indonesia Using Bovine 50k

Identification of Single Nucleotide Polymorphisms on Cattle Breeds in Indonesia Using Bovine 50k

Characterization of genes and pathways that respond to heat stress in Holstein calves through transcriptome analysis

Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression

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