A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and  in vivo

Huang, Caleb; Wei, Feng; Peh, Meng Teng; Peh, Kaye; Dymock, Brian; Moore, Philip K.

doi:10.1016/j.phrs.2016.09.032

Cited by 54 publications

(41 citation statements)

References 37 publications

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“…Allyl disulfide treatment significantly inhibited NF-κB activation and production of TNF-α, as observed by biopsies from patients with ulcerative colitis. It was shown that H 2 S donors are able to reduce TNF-α release following lipopolysaccharide (LPS) exposure in RAW 264.7 cells, a murine monocyte/macrophage-like lineage [76]. Moreover, it was recently demonstrated that H 2 S can shift the macrophage phenotype from pro-to anti-inflammatory [70,77].…”

Section: H 2 S As Inhibitor Of Oxidative Stress and Inflammationmentioning

confidence: 99%

“…At low concentration, H 2 S exerts an anti-inflammatory effect on tissue and cells, suggesting a potentially positive effect on arthritis. The effect of H 2 S on the monocyte/macrophages compartment [69,76] seems particularly relevant due to the central role that macrophages play in the pathogenesis of inflammatory arthritis. Pro-inflammatory macrophages are vital APCs and can differentiate into osteoclasts, cells responsible for irreversible bony erosions; furthermore, macrophages are one of the major sources of TNF-α.…”

Section: H 2 S and Arthritic Diseasesmentioning

confidence: 99%

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Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Sunzini

Stefano

Chimenti

et al. 2020

IJMS

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The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous gasotransmitter hydrogen sulfide (H 2 S) were recently demonstrated in the context of different inflammatory diseases. In particular, H 2 S is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of H 2 S, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in H 2 S, more evidence is needed to understand the pathophysiology and the potential of H 2 S as a therapeutic agent. Within this review, we provide an overview on H 2 S biological effects, on its role in immune-mediated inflammatory diseases, on H 2 S releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

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Section: H 2 S As Inhibitor Of Oxidative Stress and Inflammationmentioning

confidence: 99%

Section: H 2 S and Arthritic Diseasesmentioning

confidence: 99%

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Sunzini

Stefano

Chimenti

et al. 2020

IJMS

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“…Administration of H 2 S donors to animals with colitis results in faster resolution of inflammation, as well as a decreasing of pro‐inflammatory cytokine and chemokine expression relative to the control groups . Exogenous hydrogen sulfide, such as a H 2 S donor FW1256, exerts a concentration‐dependent manner in decreasing TNF‐α, IL‐6, Prostaglandin E2 (PGE2), and NO secretion in LPS‐stimulated macrophages and in vivo . Both exogenous (via H 2 S donors) and endogenous (via CSE, cystathionine gamma‐lyase) H2S production may represent approaches for managing, for example, acute gout or other inflammation conditions .…”

Section: Discussionmentioning

confidence: 99%

“…[45][46][47] Exogenous hydrogen sulfide, such as a H 2 S donor FW1256, exerts a concentration-dependent manner in decreasing TNF-α, IL-6, Prostaglandin E2 (PGE2), and NO secretion in LPS-stimulated macrophages and in vivo. 48 Both exogenous (via H 2 S donors) and endogenous (via CSE, cystathionine gamma-lyase) H2S production may represent approaches for managing, for example, acute gout or other inflammation conditions. 49 In our research, the data showed a previously unrecognized effect of H 2 S on wear debris-induced osteolysis, which prohibited osteoclastogenesis by downregulating a group of pro-inflammatory cytokines, including TNFα, IL-1β, and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide protects against particle‐induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening

et al. 2020

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Wear debris‐induced osteolysis and ensuing aseptic loosening is the main cause of implant failure and revision surgery. Wear debris‐induced inflammatory response plays key roles in peri‐implant osteolysis. Recently, substantial of evidence suggests that hydrogen sulfide (H2S), the third gasotransmitter, is a critical player regulating inflammation. However, the role and therapeutic potential of H2S in wear debris‐induced inflammation and osteolysis remains to be defined. In the present study, we investigated the effect of H2S on wear debris‐induced pro‐inflammatory cytokines expression and osteolysis in vitro and in vivo. With a slow‐releasing H2S donor GYY4137, our study demonstrated that H2S attenuated wear debris‐induced osteolysis and osteoclastogenesis in murine calvaria resorption models. The expression of tumor necrosis factor‐alpha (TNF‐α), interleukin‐1β (IL‐1β), and interleukin‐6 (IL‐6) that stimulated by wear particles were significantly reduced by GYY4137. Further, the level of sirtuin 1 (SIRT1), which possesses anti‐inflammation property, was examined in vivo and in macrophages. And we found that wear debris decreased the expression of SIRT1. Cotreated macrophages with GYY4137 in part reversed the decline of SIRT1. More importantly, with the SIRT1 recombinant lentivirus and small interfering RNAs (siRNA) against SIRT1, our data indicated that SIRT1 mediated the inhibitory effects of GYY4137 on wear debris‐induced inflammation. Collectively, these results suggested that exogenous H2S production (via H2S donors) may represent a potential approach for the treatment of wear particle‐induced osteolysis.

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“…TNF‐α is a cytokine that mediates numerous inflammatory and immunoregulatory activities and anti‐TNF therapy such as anti‐TNF‐α monoclonal antibodies and soluble TNF p75 receptor are approved treatments for immune‐mediated inflammatory diseases, such as rheumatoid arthritis, Crohn's disease, and psoriasis (Dinarello, , Feldmann & Maini , Porter et al, ). iNOS activity is involved in the pathogenesis and control of infectious diseases, tumors, autoimmune processes, and chronic degenerative diseases (Huang et al, , Uehara, de Stefano Shida, & de Brito, ). GLG inhibited Con A‐mediated increases in protein and gene expressions of TNF‐α and iNOS in isolated splenocytes.…”

Section: Discussionmentioning

confidence: 99%

Gui-ling-gao inhibits Concanavalin A-induced inflammation by suppressing the expressions of iNOS and proinflammatory cytokines in mice isolated splenocytes

Zhang

Wu²,

Guo³

et al. 2017

J Food Biochem

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Gui‐ling‐gao (GLG), also known as turtle/tortoise jelly, has been traditionally used as a functional food in southern China, Singapore, and Malaysia to regulate the immune system. In the present study, the antiinflammatory effects of GLG against Concanavalin A (Con A)‐induced inflammation in BALB/c mice isolated splenocytes were evaluated. GLG significantly (p < .05) inhibited Con A‐induced splenocyte proliferation in a concentration‐dependent manner. Con A‐mediated increases in mRNA and protein expressions of inducible nitric oxide synthase (iNOS) and tumor necrosis factor‐alpha (TNF‐α) were suppressed by GLG treatment (p < .001). GLG decreased the upregulated mRNA expressions of interleukin‐1β (IL‐1β) (p < .05) and IL‐15 (p < .001) induced by Con A. These findings suggest that GLG possesses potential antiinflammatory effects by inhibiting the expressions of iNOS and proinflammatory cytokines, such as TNF‐α, IL‐1β, and IL‐15. Practical applications The present study revealed that Gui‐ling‐gao (GLG) exhibited potential antiinflammatory effect. Thus, GLG could be employed as an effective health food for regulating immune system to cope with inflammation.

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A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo

Cited by 54 publications

References 37 publications

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases

Hydrogen sulfide protects against particle‐induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening

Gui-ling-gao inhibits Concanavalin A-induced inflammation by suppressing the expressions of iNOS and proinflammatory cytokines in mice isolated splenocytes

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