A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53

Retracted Article: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway

“…42 Previous evidence suggests that SIRT1 silencing contributes to tumor suppression in various cancers, such as breast cancer 43 and colon cancer. 44 Qu et al showed that SIRT1 promoted proliferation and inhibited apoptosis in glioma cells, thereby promoting glioma tumorigenesis. 13 Moreover, SIRT1, which catalyzes the deacetylation of non-histone proteins, has been shown to regulate mammalian cell survival under oxidative stress and DNA damage conditions.…”

p53 Expression Activation of HIV-1 Latency in U1 Cells

“…Histone Deacetylation (HDAC) represses chromatin. SIRT1 represses p53 function via deacetylation, promoting tumor growth in carcinoma cells [30] and SIRT1 inhibition increases p53 acetylation, and Bax expression and induces caspase 3 cleavages. Here, we found that p53 expression could increase acetyl transferase PCAF expression, and downregulate proteins HDAC1/2 and SIRT1 in U1 cells.…”

“…SIRT1 ((silent mating type information regulation 2 homolog) 1) is an enzyme that deacetylates proteins that contribute to cellular regulation. The HIV-1 Tat protein is a substrate for the deacetylase activity of SIRT1 which recycles Tat to its unacetylated form, catalyzing a fundamental step to start new cycles of viral transcription [30]. p53 expression significantly decreased the expression of proteins, HDAC1, HDAC2 and SIRT1 ( Figure 6B), resulting in activation of chromatin.…”

Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer

“…The nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase sirtuin 1 (SIRT1; silent mating type information regulation 2 homolog 1) has emerged as a significant target for epigenetic therapeutics of colon cancer since its increased expression is closely related to cancer progression. Additionally, SIRT1 represses p53 function via deacetylation, and so, promotes tumor growth[ 42 ]. IGF1R signaling can be improved by adipokines through SIRT1[ 43 ].…”