Increasingly, heat flux density on one chip reached to 1KW/cm 2 with the development of integration technology. However, it is hardly to meet the demand of 417K for conventional cooling way. Chip cooling become the bottleneck of integration further. This paper put forward that integrated micro channel in the chip, through which the micro fluid could transfer internal heat to the external. According to the actual working conditions, entrance flow speed and temperature could be adjusted to ensure the normal work of the chip. Firstly, analog chips model including unknown size micro channel was designed. Secondly, the ANYSIS software was adopted to find the proper size. Moreover, size 40μm micro channel could satisfy the high temperature on chip was 413K approximately. Furthermore, the situation of bi-direction flow, changed entrance velocity and entrance temperature was considered to reach the optimized result. It indicated that the chip cooling with micro-channel was feasible. Keywords-micro-channel; integrated chip cooling; the numerical simulation; micro-fluidic I.