2014
DOI: 10.1248/cpb.c14-00354
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A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT

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Cited by 11 publications
(7 citation statements)
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References 25 publications
(23 reference statements)
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“…Effects of Se on apoptosis is recorded in in vitro experiments with various cell lines including SWO-38 human glioma cells, A549/DDP human lung adenocarcinoma cells, HL-60 leukaemia cell, a549 human lung cancer cells, MCF-7 human breast adenocarcinoma cells, normal human skin fibroblasts, cervico-uterine cancer cells and prostate cancer cells. These experiments have used a variety of inorganic and organic Se supplements including sodium selenite, SeMet, modified Se nanoparticles, methylseleninic acid, Se-containing phycocyanin (Se-PC) and 22-oxo-26-selenocyanocholestane [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Hawkes et al have carried out a Se supplementation study with 16 healthy men for 1 year with 300 μg/day of high selenized yeast or placebo.…”
Section: Discussionmentioning
confidence: 99%
“…Effects of Se on apoptosis is recorded in in vitro experiments with various cell lines including SWO-38 human glioma cells, A549/DDP human lung adenocarcinoma cells, HL-60 leukaemia cell, a549 human lung cancer cells, MCF-7 human breast adenocarcinoma cells, normal human skin fibroblasts, cervico-uterine cancer cells and prostate cancer cells. These experiments have used a variety of inorganic and organic Se supplements including sodium selenite, SeMet, modified Se nanoparticles, methylseleninic acid, Se-containing phycocyanin (Se-PC) and 22-oxo-26-selenocyanocholestane [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Hawkes et al have carried out a Se supplementation study with 16 healthy men for 1 year with 300 μg/day of high selenized yeast or placebo.…”
Section: Discussionmentioning
confidence: 99%
“…37 Other studies have shown the effect of organoselenium, such as diphenyl diselenide and selenadiazole in gliomas. 38,39 However, to our knowledge, this is the first work showing the antiglioma potential of an organochalcogen-containing propynyl benzoates. The main mechanism by which organochalcogen, mainly organoselenium compounds, are considered promising antitumor agents is in their broad antioxidant effect.…”
Section: Accepted Manuscriptmentioning
confidence: 92%
“…127 1,2,5-Selenadiazole-DAB derivative 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (VIII-55 in Figure 8) was shown to induce apoptosis in SWO-38 glioma cells by AKT dephosphorylation. 128 Derivatization of the previous 1,2diamine to diaryl quinoxalines (VIII-56 in Figure 8) yielded other 1,2,5-selenadiazolic compounds able to enhance X-ray sensitization on A375 human melanoma and HeLa cells by induction of cell cycle arrest. 129 Chemo-and radio-combined treatment pointed out to a TrxR activity inhibition.…”
Section: 24-selenadiazolesmentioning
confidence: 99%