A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT

Zhang, Yikai; Zheng, Shanyuan; Ngai, Sai-Ming; Zheng, Wenjie; Li, Jinying; Chen, Tianfeng; Zhong, Xueyun

doi:10.1248/cpb.c14-00354

Cited by 11 publications

(7 citation statements)

References 25 publications

(23 reference statements)

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“…Effects of Se on apoptosis is recorded in in vitro experiments with various cell lines including SWO-38 human glioma cells, A549/DDP human lung adenocarcinoma cells, HL-60 leukaemia cell, a549 human lung cancer cells, MCF-7 human breast adenocarcinoma cells, normal human skin fibroblasts, cervico-uterine cancer cells and prostate cancer cells. These experiments have used a variety of inorganic and organic Se supplements including sodium selenite, SeMet, modified Se nanoparticles, methylseleninic acid, Se-containing phycocyanin (Se-PC) and 22-oxo-26-selenocyanocholestane [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. Hawkes et al have carried out a Se supplementation study with 16 healthy men for 1 year with 300 μg/day of high selenized yeast or placebo.…”

Section: Discussionmentioning

confidence: 99%

Benefits of Selenium Supplementation on Leukocyte DNA Integrity Interact with Dietary Micronutrients: A Short Communication

2016

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A male cohort from New Zealand has previously shown variability in Selenium (Se) supplementation effects on measured biomarkers. The current analysis is to understand the reasons for variability of the H2O2-induced DNA damage recorded after Se supplementation. We have looked at the variation of demographic, lifestyle, medication, genetic and dietary factors and biomarkers measured at baseline and post-supplementation in these two extreme subgroups A and B. Group A showed increased H2O2-induced DNA damage and group B showed decreased damage after Se supplementation. We have also considered correlations of biomarkers and dietary factors in the complete dataset. The glutathione peroxidase (GPx) activity and DNA damage were significantly lower at post-supplementation in Group B compared to Group A. Post-supplementation, Group B showed a significant reduction in the GPx activity, while Group A showed a significant increase in DNA damage compared to baseline levels. Dietary methionine intake was significantly higher and folate intake was significantly lower in Group B compared to Group A. Se supplementation significantly increased the caspase-cleaved keratin 18 levels in both groups, indicating increased apoptotic potential of this supplement. Parameter correlation with the complete dataset showed dietary methionine to have a significant negative correlation with H2O2-induced DNA damage post-supplementation. The data suggest that Se supplementation is beneficial for the leukocyte DNA integrity only in interaction with the dietary methionine and folate intake.

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Section: Discussionmentioning

confidence: 99%

Benefits of Selenium Supplementation on Leukocyte DNA Integrity Interact with Dietary Micronutrients: A Short Communication

2016

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“…37 Other studies have shown the effect of organoselenium, such as diphenyl diselenide and selenadiazole in gliomas. 38,39 However, to our knowledge, this is the first work showing the antiglioma potential of an organochalcogen-containing propynyl benzoates. The main mechanism by which organochalcogen, mainly organoselenium compounds, are considered promising antitumor agents is in their broad antioxidant effect.…”

Section: Accepted Manuscriptmentioning

confidence: 92%

Base-Free Synthesis and Synthetic Applications of Novel 3-(Organochalcogenyl)prop-2-yn-1-yl Esters: Promising Anticancer Agents

et al. 2021

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This manuscript portrays the CuI-catalyzed Csp-chalcogen bond formation through cross-coupling reactions of propynyl esters and diorganyl dichalcogenides by using DMSO as solvent, at room temperature, under base-free and open-to-air atmosphere. Generally, the reactions have proceeded very smoothly, being tolerant to range of substituents present in both substrates, affording the novel 3-(organochalcogenyl)prop-2-yn-1-yl esters in moderate to good yields. Noteworthy, the 3-(butylselanyl)prop-2-yn-1-yl benzoate proved to be useful as synthetic precursor in palladium-catalyzed Suzuki and Sonogashira type cross-coupling reactions by replacing the carbon-chalcogen bond by new carbon-carbon bonds. Moreover, the 3-(phenylselanyl)prop-2-yn-1-yl benzoate has shown promising in vitro activity against glioblastoma cancer cells.

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“…127 1,2,5-Selenadiazole-DAB derivative 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (VIII-55 in Figure 8) was shown to induce apoptosis in SWO-38 glioma cells by AKT dephosphorylation. 128 Derivatization of the previous 1,2diamine to diaryl quinoxalines (VIII-56 in Figure 8) yielded other 1,2,5-selenadiazolic compounds able to enhance X-ray sensitization on A375 human melanoma and HeLa cells by induction of cell cycle arrest. 129 Chemo-and radio-combined treatment pointed out to a TrxR activity inhibition.…”

Section: 24-selenadiazolesmentioning

confidence: 99%

Development and Therapeutic Potential of Selenazo Compounds

et al. 2019

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Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, antiinflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.

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A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT

Cited by 11 publications

References 25 publications

Benefits of Selenium Supplementation on Leukocyte DNA Integrity Interact with Dietary Micronutrients: A Short Communication

Benefits of Selenium Supplementation on Leukocyte DNA Integrity Interact with Dietary Micronutrients: A Short Communication

Base-Free Synthesis and Synthetic Applications of Novel 3-(Organochalcogenyl)prop-2-yn-1-yl Esters: Promising Anticancer Agents

Development and Therapeutic Potential of Selenazo Compounds

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