A novel selective mitochondrial-targeted curcumin analog with remarkable cytotoxicity in glioma cells

Design, Synthesis, Biological Evaluation, and Preliminary Mechanistic Study of a Novel Mitochondrial-Targeted Xanthone

“…The difference in electric potential between the two membranes is called mitochondrial membrane potential (Δψ m ), which is much higher in tumor cells than that in normal cells [ 3 ]. Therefore, using this feature, some positively charged drug molecules or agents such as rhodamine 123, dequalinium, guanidinium, and triphenylphosphonium (TPP) cations can be driven by Δψ m to accumulate in mitochondria and achieve targeted antitumor effects able to destroy cancer cells [ 6 , 7 , 8 ].…”

A triphenylphosphine coordinated Cu(i) Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy

“…The terminal triphenylphosphine helps the materials to internalize into cancer cells efficiently. 29–31 For comparison, we also synthesized Ba-OD-Cu (benzaldehyde oxalohyldihydrazone copper complex) and Fc-OD (ferrocenecarboxaldehyde oxalohyldihydrazone). The MB and ESR experiments showed that Fc-OD-Cu had better ˙OH generation efficiency than Ba-OD-Cu and Fc-OD .…”

Rational construction of a triphenylphosphine-modified tetra-nuclear Cu(i) coordinated cluster for enhanced chemodynamic therapy

“…Additionally, the terminal triphenylphosphine helps the materials to internalize into cancer cells efficiently. 17–19 Compared with 2 , upon increasing the number of metal centers in 1 , methylene blue (MB) degradation experiments exhibited more efficient Fenton-like reactivity. A cell uptake measurement showed the accumulation of a larger amount of copper metal.…”