A Novel Screening Biomarker in Gastric Cancer: Serum Dickkopf-1

Abstract

Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers.

Interaction between Wnt/β-catenin pathway and microRNAs regulates epithelial-mesenchymal transition in gastric cancer (Review)

“…Than et al (81) reported that administration of adenovirus vector carrying REIC/DKK-3 (Ad-REIC/DKK-3) can inhibit scirrhous gastric carcinoma (SGC) both in vitro and in nude mice by boosting apoptosis and recruitment of NK cells. On the contrary, despite DKK-1 or DKK-3 being Wnt suppressors, these protein have been detected upregulated in GC as well as significantly correlated to pT-stage and UICC stage (82,83), revealing that DKKs could have potential in oncogenesis of gastric cancer rather than as tumor inactivators, which might be explained either as a negative feedback loop in response to initial Wnt/β-catenin signaling activation or mediation by non-canonical Wnt pathways (84). Shin et al (85) sought to assess the role of secreted frizzled-related proteins (SFRPs) as antagonist of Wnt pathway and confirmed that aber rant methylation of SFRPs is the major mechanism by which Wnt signaling is activated in human GC cells.…”

Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

“…(Sato et al, 2010;Kemik et al, 2011;Gomceli et al, 2012;Jiang, Huang, Zhang, 2013;Yang et al, 2013).…”

“…Some studies have demonstrated over-expression of DKK-1 in patients with Wilms tumor, hepatoblastoma, hepatocellular carcinoma, gastric cancer, rectal cancer, colon cancer, gynecological cancers, indicating that DKK-1 has a latent oncogenic role in these tumors (Wirths et al, 2003;Patil et al, 2005;Jianget al, 2009;Kemik et al, 2011;Soydinc et al, 2011;Tung et al, 2011;Gomceli et al, 2012;Lee et al, 2012).…”

Involvement of Mitochondrial Reactive Oxygen Species in Gastric Carcinogenesis

“…However, the mechanisms that control gastric cancer invasion and metastasis have not been clarified yet. The ability of gastric cancer cell invasion is related to mutations in both oncogenes and tumor suppressor genes, and is affected by growth factors, inflammatory cytokines and angiogenesis [50][51][52]. In addition, cancer cellular ROS may also play an important role in their invasion and metastasis [53,54] because ROS regulate activation of actin remodeling proteins and focal adhesion proteins [55,56].…”