A novel sandwich aptasensor for detecting T-2 toxin based on rGO-TEPA-Au@Pt nanorods with a dual signal amplification strategy

Zhong, Hangtian; Yu, Chao; Gao, Rufei; Chen, Jun; Yu, Yujie; Geng, Yanqing; Wen, Yilin; He, Junlin

doi:10.1016/j.bios.2019.111635

Cited by 54 publications

(17 citation statements)

References 26 publications

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“…Additionally, aptamers are more stable than antigens, and can easily recover their active spatial configuration after usage thereby allowing for the reuse of the same electrode multiple times [85]. Based on how the immobilized aptamers interact with the target analyte, Han and coworkers proposed the following categories: (a) spatial configuration rearrangement of aptamers based on target interaction [86][87][88]; (b) sandwich type interactions [89][90][91]; (c) dissociation or displacement of aptamers through target interaction [92,93]; and (d) competitive replacement of aptamers [14,[94][95][96].…”

Section: Ecbs Operating Through Bioaffinitymentioning

confidence: 99%

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Ecbs Operating Through Bioaffinitymentioning

confidence: 99%

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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“…To address these issues, improving performance of working electrodes and achieving signal amplification have become necessary. Commonly used working electrodes such as glass carbon, gold, and silver electrodes have recently been modified with various nanomaterials (carbon nanotubes, graphene oxide, metal nanoparticles, thin-layer MoS 2 , and porous metal organic framework) to increase their surface area [110][111][112][113]. As a result, the nanostructured rough electrode surface can be immobilized with more recognition reagents and more sufficient contact with the analytes so that sensitivity and conductivity are greatly improved [114].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods

Yang

Wang

et al. 2021

J Animal Sci Biotechnol

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Mycotoxins are secondary metabolites produced by fungus. Many mycotoxin species are highly toxic and are frequently found in cereals and feedstuffs. So, powerful detection methods are vital and effective ways to prevent feed contamination. Traditional detection methods can no longer meet the needs of massive, real-time, simple, and fast mycotoxin monitoring. Rapid detection methods based on advanced material and sensor technology are the future trend. In this review, we highlight recent progress of mycotoxin rapid detection strategies in feedstuffs and foods, especially for simultaneous multiplex mycotoxin determination. Immunoassays, biosensors, and the prominent roles of nanomaterials are introduced. The principles of different types of recognition and signal transduction are explained, and the merits and pitfalls of these methods are compared. Furthermore, limitations and challenges of existing rapid sensing strategies and perspectives of future research are discussed.

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“…Owing to the high stability, low cost, and convenient labeling, nanoparticles can also serve as signal probes for DNA detection to further improve the performance of sandwich assays [106][107][108][109][110][111][112][113][114][115]. For example, Zhang et al [116] reported a nanoparticle based "sandwich" detection strategy by immobilizing gold nanoparticles (AuNPs) with reporter probes that flank the target nucleic acids.…”

Section: +mentioning

confidence: 99%

Nucleic Acids Analysis

Zhao

Zuo

et al. 2020

Sci. China Chem.

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In recent years, multi-modal entity linking (MEL) has garnered increasing attention in the research community due to its significance in numerous multi-modal applications. Video, as a popular means of information transmission, has become prevalent in people's daily lives. However, most existing MEL methods primarily focus on linking textual and visual mentions or offline videos's mentions to entities in multi-modal knowledge bases, with limited efforts devoted to linking mentions within online video content. In this paper, we propose a task called Online Video Entity Linking (OVEL), aiming to establish connections between mentions in online videos and a knowledge base with high accuracy and timeliness. To facilitate the research works of OVEL, we specifically concentrate on live delivery scenarios and construct a live delivery entity linking dataset called LIVE. Besides, we propose an evaluation metric that considers timelessness, robustness, and accuracy. Furthermore, to effectively handle OVEL task, we leverage a memory block managed by a Large Language Model and retrieve entity candidates from the knowledge base to augment LLM performance on memory management. The experimental results prove the effectiveness and efficiency of our method.

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A novel sandwich aptasensor for detecting T-2 toxin based on rGO-TEPA-Au@Pt nanorods with a dual signal amplification strategy

Cited by 54 publications

References 26 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods

Nucleic Acids Analysis

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