A Novel Route to Substituted 2‐(N‐Arylamino)benzothiazoles via Iron‐Promoted C‐S Bond Formation

Abstract

The synthesis of 2‐aminobenzothiazoles has been demonstrated in the presence of transition metal under mild reaction conditions. In this paper, disubstituted thioureas have also been reported from isothiocyanates at room temperature. Subsequently, C−S cross‐coupling reaction was described for the construction of benzothiazoles using cheap, readily available and air stable Iron catalyst. Moreover, no other byproducts could be observed except target products. Furthermore, control experiments were performed for reveal the mechanism. In addition, a broad range of substrate scope has been explored.

Copper‐Oxone Promoted Oxidative C−H Functionalization: Synthesis of 2‐Aminobenzothiazoles and Evaluation of Their Antimicrobial Activities

“…[18] Several efficient catalytic systems have been developed for the intramolecular CÀ S bond formation based on the CÀ H functionalization. [19] Although palladium-, [15,20] copper(II)-, [18] ruthenium-, [21] and iron-catalyzed [22] intramolecular cyclization of thioureas for the synthesis of the 2-aminobenzothiazoles have been reported, copper(I)-catalyzed cyclization has not described in the literature before. There are some examples where the copper(I)-catalyst is used only in the cyclization reactions of ortho-halothiourea derivatives.…”