A Novel Route to an Aminophosphonic Acid by Thermolysis of a Poly(urethane Phosphonate). The Betain Form of 3-Ethyl-2-Hydroxy-2-Oxo-1,4,2-Oxaza-Phosphorinane. Structure and Properties

Troev, K.; Hägele, Gerhard; Kreidler, Kay; Olschner, Ralf; Verwey, Claudia; Roundhill, D. Max

doi:10.1080/10426509908037008

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Cited by 7 publications

(1 citation statement)

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“…• C) resulted in 3-ethyl-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane (8), a hitherto nondescribed cyclic α-aminophosphonic acid (Scheme 1) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Novel routes to aminophosphonic acids: Interaction of dimethyl H‐phosphonate with hydroxyalkyl carbamates

Troev

Koseva

Hägele

2008

Heteroatom Chemistry

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“…• C) resulted in 3-ethyl-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane (8), a hitherto nondescribed cyclic α-aminophosphonic acid (Scheme 1) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Novel routes to aminophosphonic acids: Interaction of dimethyl H‐phosphonate with hydroxyalkyl carbamates

Troev

Koseva

Hägele

2008

Heteroatom Chemistry

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Synthesis, cytotoxicity and clastogenicity of novel α-aminophosphonic acids

et al. 2006

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Alpha-ethyl-N-(phosphonomethyl) glycine is synthesized and characterized by NMR and FAB spectroscopy. The cytotoxicity, clastogenic and antiproliferative effect of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, sodium salt of 3-ethyl-2-hydroxyl-2-oxo-1,4,2-oxazaphosphorinane, alpha-ethyl-alpha-N-(hydroxyethylamino) methylphosphonic acid, alpha-ethyl-N-(phosphonomethyl) glycine, alpha-ethyl-N-(phosphonomethyl) glycine isopropylammonium salt, glyphosate isopropylammonium salt are tested.

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Recent synthesis of aminophosphonic acids as potential biological importance

2009

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Aminophosphonic acids are an important group of medicinal compounds, and their synthesis has been a focus of considerable attention in synthetic organic chemistry as well as medicinal chemistry. Although the phosphonic and carboxylic acid groups differ considerably with respect to shape, size, and acidity, alpha-aminophosphonic acids are considered to be structural analogues of the corresponding amino acids and the transition state mimics peptide hydrolysis. This review summarizes recent developments in the synthesis, characterization and biological activity of alpha-aminophosphonic acid and N-analogues. An account of both uses will be presented, emphasizing one of the potential future developments, and some implications in medicinal chemistry are also disclosed. In addition, a brief account on the characterization of N-(phosphonomethyl) glycine derivatives will be presented.

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A Novel Route to an Aminophosphonic Acid by Thermolysis of a Poly(urethane Phosphonate). The Betain Form of 3-Ethyl-2-Hydroxy-2-Oxo-1,4,2-Oxaza-Phosphorinane. Structure and Properties

Cited by 7 publications

References 12 publications

Novel routes to aminophosphonic acids: Interaction of dimethyl H‐phosphonate with hydroxyalkyl carbamates

Novel routes to aminophosphonic acids: Interaction of dimethyl H‐phosphonate with hydroxyalkyl carbamates

Synthesis, cytotoxicity and clastogenicity of novel α-aminophosphonic acids

Recent synthesis of aminophosphonic acids as potential biological importance

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