A novel route for the synthesis of macroporous bioceramics for bone regeneration

Dapporto, Massimiliano; Sprio, Simone; Fabbi, Claudia; Figallo, Elisa; Tampieri, Anna

doi:10.1016/j.jeurceramsoc.2015.10.020

Cited by 21 publications

(21 citation statements)

References 45 publications

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“…In conclusion, the HA_1 preparation process was scaled up successfully, and the HA_5 sample is suitable in terms of SSA to be used for scaffold fabrication by foaming. Indeed, HA_5 had a value of SSA comparable to HA-based materials that were previously used for preparing 3D scaffolds by direct foaming technique [25].…”

Section: Preparation and Characterization Of Ha Samplesmentioning

confidence: 84%

“…Moreover, to compare the effect of the gaseous atmosphere on the composition and the specific surface area (SSA) of the samples, thermal treatments were performed in N2 or air. Once the conditions were optimized, the process of synthesis of HA was scaled up at the pilot level, and the obtained powder was employed to fabricate porous scaffolds using the already reported direct foaming method ( Figure 2) [25]. This method has also been selected due to its low economic and environmental impact since it does not use sacrificial templates for obtaining scaffolds.…”

Section: Preparation and Characterization Of Cao Samples From Mussel mentioning

confidence: 99%

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Mussel Shell-Derived Macroporous 3D Scaffold: Characterization and Optimization Study of a Bioceramic from the Circular Economy

et al. 2020

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Fish industry by-products constitute an interesting platform for the extraction and recovery of valuable compounds in a circular economy approach. Among them, mussel shells could provide a calcium-rich source for the synthesis of hydroxyapatite (HA) bioceramics. In this work, HA nanoparticles have been successfully synthesized starting from mussel shells (Mytilus edulis) with a two steps process based on thermal treatment to convert CaCO3 in CaO and subsequent wet precipitation with a phosphorus source. Several parameters were studied, such as the temperature and gaseous atmosphere of the thermal treatment as well as the use of two different phosphorus-containing reagents in the wet precipitation. Data have revealed that the characteristics of the powders can be tailored, changing the conditions of the process. In particular, the use of (NH4)2HPO4 as the phosphorus source led to HA nanoparticles with a high crystallinity degree, while smaller nanoparticles with a higher surface area were obtained when H3PO4 was employed. Further, a selected HA sample was synthesized at the pilot scale; then, it was employed to fabricate porous 3D scaffolds using the direct foaming method. A highly porous scaffold with open and interconnected porosity associated with good mechanical properties (i.e., porosity in the range 87–89%, pore size in the range 50–300 μm, and a compressive strength σ = 0.51 ± 0.14 MPa) suitable for bone replacement was achieved. These results suggest that mussel shell by-products are effectively usable for the development of compounds of high added value in the biomedical field.

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Section: Preparation and Characterization Of Ha Samplesmentioning

confidence: 84%

Section: Preparation and Characterization Of Cao Samples From Mussel mentioning

confidence: 99%

Mussel Shell-Derived Macroporous 3D Scaffold: Characterization and Optimization Study of a Bioceramic from the Circular Economy

et al. 2020

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“…Due to controlled macroporosity and pore interconnection obtained by this flexible method, scaffolds not only exhibit improved osteoconductive ability but also higher mechanical properties than those obtained using sacrificial templates [24]. A recent study reported a novel promising route based on a modified direct foaming method that gave HA bodies with 65% pore volume and a compressive strength σ = 16.3 ± 4.3 MPa [27].…”

Section: Porous Hydroxyapatite Scaffolds For Bone Regenerationmentioning

confidence: 99%

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

Preti¹,

Lambiase²,

Campodoni³

et al. 2019

Bio-Inspired Technology [Working Title]

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Material scientists are increasingly looking to natural structures as inspiration for new-generation functional devices. Particularly in the medical field, the need to regenerate tissue defects claims, since decades, biomaterials with the ability to instruct cells toward formation and organization of new tissue. It is today increasingly accepted that biomimetics is a leading concept for biomaterials development. In fact, there is increasing evidence that the use of biomedical devices showing substantial mimicry of the composition and multi-scale structure of target native tissues have enhanced regenerative ability. As a relevant example, biomimetic materials have high potential to solve degenerative diseases affecting the musculoskeletal system, namely, bone, cartilage and articular tissues, which is of pivotal importance for most of human abilities, such as walking, running, manipulating, and chewing. In this respect, the adoption of nature-inspired processes and structures is an emerging fabrication concept, uniquely able to provide biomaterials with superior biological performance. The chapter will give an overview of the most recent results obtained in the field of hard tissue regeneration by using 3D biomaterials obtained by nature-inspired approaches. The main focus is given to porous hydroxyapatitebased ceramic or hybrid scaffolds for regeneration of bone and osteochondral tissues in neurosurgery and orthopedics.

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“…In particular, the direct foaming method was stated to be a low-cost and easy process that can provide pore volumes in the range 40-97% by incorporating air into a ceramic suspension that is subsequently dried and sintered. It was also reported that cellular structures prepared by direct foaming usually exhibit considerably higher mechanical strength than those obtained by other template-based techniques, mainly due to the strongly reduced occurrence of flaws in the cell struts [64,65]. The decisive step in direct foaming methods is related to the development of ceramic slurries with optimal rheological properties, so that they can be dried and physically stabilized upon pouring into preshaped containers, while maintaining the shape, size, and distribution of the air bubbles.…”

Section: Designing Porous Calcium Phosphate/titania Scaffolds Exploitmentioning

confidence: 99%

Composite Calcium Phosphate/Titania Scaffolds in Bone Tissue Engineering

Dapporto¹,

Tampieri²,

Sprio³

2017

Application of Titanium Dioxide

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Titanium and its alloys have been extensively used as implantation materials due to their favorable properties such as lower modulus, good tensile strength, excellent biocompatibility, and enhanced corrosion resistance. However, their intrinsic bioinertness generally prevents a direct bond with the bone on the surface especially at an early stage of implantation. In recent years, bioactive scaffolds for bone regeneration are progressively replacing bioinert prostheses in orthopedic, maxillofacial, and neurosurgery fields. Given the need of enhanced mechanical strength, several combinations of bioactive and reinforcing phases have been studied, but still no convincing solutions have been found so far. In this context, titanium oxides are light and high-resistance bioactive materials widely employed in dental and bone application due to their capacity of forming strong bonds with bone tissue via the formation of a tightly bound apatite layer on their surface. The addition of titania particles to hydroxyapatite has attracted considerable attention based on the assumption that resulting materials can enhance osteoblast adhesion and promote cell growth while also providing high strength and fracture toughness in the final composite material, thus being adequate for load-bearing applications.

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A novel route for the synthesis of macroporous bioceramics for bone regeneration

Cited by 21 publications

References 45 publications

Mussel Shell-Derived Macroporous 3D Scaffold: Characterization and Optimization Study of a Bioceramic from the Circular Economy

Mussel Shell-Derived Macroporous 3D Scaffold: Characterization and Optimization Study of a Bioceramic from the Circular Economy

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

Composite Calcium Phosphate/Titania Scaffolds in Bone Tissue Engineering

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