A Novel Role of Secretory Cytosolic Tryparedoxin Peroxidase in Delaying Apoptosis of <i>Leishmania</i>-Infected Macrophages

Das, Sanchita; Saha, Tanaya; Yadav, S.; Shaha, Chandrima

doi:10.1128/mcb.00081-22

Cited by 1 publication

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“…Exoproteome analysis of L. donovani revealed that the parasite secretes a repertoire of secretory molecules including, molecules for immunomodulation and evasion [glycoprotein 63 (gp63), elongation factor 1α (EF1α), oligopeptidase, proteophosphoglycan (PPG)], increased pathogenicity [chitinase, casein kinase, KMP-11, cysteine peptidase and metalloproteases], and parasite protection [tryparedoxin peroxidase (cTXNPx)], which influence the pathophysiology of the disease by induction of inflammatory cytokines, particularly IL-17a [ 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 ] and/or implicated in drug-resistance in parasites [ 155 ]. Exosomes secreted by drug-resistant parasite form a nucleosome complex with human histone in host chromatin during the progression of the disease [ 156 ].…”

Section: Ltps and Their Biological Implicationsmentioning

confidence: 99%

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction

Das

Nozaki

2023

IJMS

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Eukaryotic cells have distinct membrane-enclosed organelles, each with a unique biochemical signature and specialized function. The unique identity of each organelle is greatly governed by the asymmetric distribution and regulated intracellular movement of two important biomolecules, lipids, and proteins. Non-vesicular lipid transport mediated by lipid-transfer proteins (LTPs) plays essential roles in intra-cellular lipid trafficking and cellular lipid homeostasis, while vesicular transport regulates protein trafficking. A comparative analysis of non-vesicular lipid transport machinery in protists could enhance our understanding of parasitism and basis of eukaryotic evolution. Leishmania donovani, the trypanosomatid parasite, greatly depends on receptor-ligand mediated signalling pathways for cellular differentiation, nutrient uptake, secretion of virulence factors, and pathogenesis. Lipids, despite being important signalling molecules, have intracellular transport mechanisms that are largely unexplored in L. donovani. We have identified a repertoire of sixteen (16) potential lipid transfer protein (LTP) homologs based on a domain-based search on TriTrypDB coupled with bioinformatics analyses, which signifies the presence of well-organized lipid transport machinery in this parasite. We emphasized here their evolutionary uniqueness and conservation and discussed their potential implications for parasite biology with regards to future therapeutic targets against visceral leishmaniasis.

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Section: Ltps and Their Biological Implicationsmentioning

confidence: 99%

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction

Das

Nozaki

2023

IJMS

View full text Add to dashboard Cite

show abstract

A Novel Role of Secretory Cytosolic Tryparedoxin Peroxidase in Delaying Apoptosis of Leishmania-Infected Macrophages

Abstract: The cytosolic tryparedoxin peroxidase (cTXNPx) of Leishmania donovani is a defensive enzyme. Apart from the nonsecretory form, the cTXNPx is released in the spent media of Leishmania cultures and also in the host cell cytosol.

Cited by 1 publication

References 50 publications

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction

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