A Novel Role of CD38 and Oxytocin as Tandem Molecular Moderators of Human Social Behavior

Tolomeo, Serenella; Chiao, Benjamin; Lei, Zhen; Chew, Soo Hong; Ebstein, Richard P.

doi:10.1016/j.neubiorev.2020.04.013

Cited by 26 publications

(19 citation statements)

References 178 publications

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“…It has been established that OT is not only secreted from the posterior pituitary into the circulation but is also released in the brain, where it has very diverse behavioral effects ( Russell et al, 2003 ; Leng et al, 2015 ; Higashida, 2016 ; Russell, 2018 ). Hypothalamic neurons secrete oxytocin (OT) into the brain from dendrites and axons to function as an endogenous factor in species-specific social memory and behaviors, including emotion, interaction, and bonds ( Baumgartner et al, 2008 ; Bridges, 2015 ; Huang et al, 2015 ; Numan and Young, 2016 ; Feldman, 2017 ; Higashida et al, 2018 , 2019a , b ; Jurek and Neumann, 2018 ; Borowiak and von Kriegstein, 2020 ; Carter et al, 2020 ; Quintana and Guastella, 2020 ; Tolomeo et al, 2020 ; Froemke and Young, 2021 ; Grinevich and Neumann, 2021 ; Yeomans et al, 2021 ; Zheng and Kendrick, 2021 ; Carter, 2022 ). CD38 and CD157 play an essential role in central OT release ( Jin et al, 2007 ; Higashida et al, 2017b ).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

et al. 2022

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Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain from the peripheral circulation. To date, of these, many studies provide evidence that CD38, CD157, and receptor for advanced glycation end-products (RAGE) act as regulators of OT concentrations in the brain and blood. It has been shown that RAGE facilitates the uptake of OT in mother’s milk from the digestive tract to the cell surface of intestinal epithelial cells to the body fluid and subsequently into circulation in male mice. RAGE has been shown to recruit circulatory OT into the brain from blood at the endothelial cell surface of neurovascular units. Therefore, it can be said that extracellular OT concentrations in the brain (hypothalamus) could be determined by the transport of OT by RAGE from the circulation and release of OT from oxytocinergic neurons by CD38 and CD157 in mice. In addition, it has recently been found that gavage application of a precursor of nicotinamide adenine dinucleotide, nicotinamide riboside, for 12 days can increase brain OT in mice. Here, we review the evaluation of the new concept that RAGE is involved in the regulation of OT dynamics at the interface between the brain, blood, and intestine in the living body, mainly by summarizing our recent results due to the limited number of publications on related topics. And we also review other possible routes of OT recruitment to the brain.

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Section: Introductionmentioning

confidence: 99%

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

et al. 2022

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“…Thus, CD38 acts as an important modulator of immune function. Similarly, in the context of OXT secretion, the role of CD38 has already been established (Refs 185, 186). This protein through its enzymatic function mediates ADP-ribose (ADPR) and cyclic ADPR (cADPR) production, extracellular signal-regulated kinase (ERK1/2) activation, and Ca 2+ mobilisation, processes triggering OXT release (Ref.…”

Section: Molecular Mechanisms Of Social Environmentmentioning

confidence: 88%

Social environment as a modulator of immunosenescence

Garrido

Toda

Cerro

et al. 2022

Expert Rev. Mol. Med.

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Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer. Nonetheless, differences in how individuals of the same chronological age carry out this immunosenescence establishment and thus the aging rate have been reported. In the context of neuroimmunoendocrine communication and its role in the response to stress situations, growing evidence suggests that social environments profoundly influence all physiological responses, especially those linked to immunity. Accordingly, negative contexts (loneliness in humans/social isolation in rodents) were associated with immune impairments and decreased lifespan. However, positive social environments have been correlated with adequate immunity and increased lifespan. Therefore, the social context in which an individual lives is proposed as a decisive modulator of the immunosenescence process and, consequently, of the rate of aging. In this review, the most important findings regarding how different social environments (negative and positive) modulate immunosenescence and therefore the aging rate, as well as the role of stress responses, hormesis, and resilience in these environments will be explained. Finally, several possible molecular mechanisms underlying the effects of negative and positive environments on immunosenescence will be suggested.

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“…The interest to them was not accidental. Oxytocin is an important modulator of human associative behavior including social skills, pair bonding, parental affection and friendship, confidence formation [ 107 ]. Oxytocin is involved in the regulation of repetitive and affiliative behavior which is a key factor for autism development.…”

Section: Systemic Approaches To the Study Of Autism Spectrum Disordersmentioning

confidence: 99%

“…It is supposed that activation of the immune system which may be connected with ASD development in children depends on mother’s IL-6. Besides, IL-6 plays a critical role in the development and modulation of autistic behavior due to the disorders in neuronal network formation [ 107 ].…”

Section: Systemic Approaches To the Study Of Autism Spectrum Disordersmentioning

confidence: 99%

Molecular Mechanisms of Aberrant Neuroplasticity in Autism Spectrum Disorders (Review)

Anashkina¹,

Ерлыкина²

2021

Sovrem Tehnol Med

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This review presents the analysis and systematization of modern data on the molecular mechanisms of autism spectrum disorders (ASD) development. Polyetiology and the multifactorial nature of ASD have been proved. The attempt has been made to jointly review and systematize current hypotheses of ASD pathogenesis at the molecular level from the standpoint of aberrant brain plasticity. The mechanism of glutamate excitotoxicity formation, the effect of imbalance of neuroactive amino acids and their derivatives, neurotransmitters, and hormones on the ASD formation have been considered in detail. The strengths and weaknesses of the proposed hypotheses have been analyzed from the standpoint of evidence-based medicine. The conclusion has been drawn on the leading role of glutamate excitotoxicity as a biochemical mechanism of aberrant neuroplasticity accompanied by oxidative stress and mitochondrial dysfunction. The mechanism of aberrant neuroplasticity has also been traced at the critical moments of the nervous system development taking into account the influence of various factors of the internal and external environment. New approaches to searching for ASD molecular markers have been considered.

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A Novel Role of CD38 and Oxytocin as Tandem Molecular Moderators of Human Social Behavior

Cited by 26 publications

References 178 publications

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Social environment as a modulator of immunosenescence

Molecular Mechanisms of Aberrant Neuroplasticity in Autism Spectrum Disorders (Review)

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