2009
DOI: 10.1002/jcp.21729
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A novel role for the TRPV1 channel in UV‐induced matrix metalloproteinase (MMP)‐1 expression in HaCaT cells

Abstract: Transient receptor potential vanilloid type 1 (TRPV1) is a molecular sensor for detecting adverse stimuli, such as capsaicin, heat, and acid. TRPV1 has been localized in keratinocytes and is suggested to be a mediator of heat-induced matrix metalloproteinase-1 (MMP-1). With regard to the multimodal activation of TRPV1, we hypothesize that TRPV1 might also mediate UV-induced MMP-1 in keratinocytes. In HaCaT, a human keratinocyte cell line, we initially confirmed capsaicin-induced membrane current and Ca(2+) inf… Show more

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Cited by 92 publications
(77 citation statements)
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References 53 publications
(56 reference statements)
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“…The protective effects of p-CA against the UV-induced inflammatory responses or injury has been previously observed in cells and in vivo models [32][33][34]. We suppose that p-CA is one of the active constituents of BCTE based on the observations in the current study, but other studies reported that BCTE contained various other constituents with antioxidant properties [16,17]. Thus, the activity of BCTE can be attributed to the multiple constituents rather than any single compound.…”
Section: Discussionsupporting
confidence: 63%
See 1 more Smart Citation
“…The protective effects of p-CA against the UV-induced inflammatory responses or injury has been previously observed in cells and in vivo models [32][33][34]. We suppose that p-CA is one of the active constituents of BCTE based on the observations in the current study, but other studies reported that BCTE contained various other constituents with antioxidant properties [16,17]. Thus, the activity of BCTE can be attributed to the multiple constituents rather than any single compound.…”
Section: Discussionsupporting
confidence: 63%
“…These MMPs can regulate connective tissue remodeling leading to the formation of wrinkles, and other phenotypes of photoaged skin [14,15]. MMP1 secreted not only from dermal fibroblasts and but from epidermal keratinocytes is known to participate in collagen destruction in the skin [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…In skin, TRPV1 is also expressed in keratinocytes and fibroblasts (28). TRPV1 activation is involved in inflammatory responses in human keratinocytes through the release of inflammatory mediators, such as prostaglandin E 2 and interleukin-8 (28), and UV irradiation-increased MMP-1 is mediated by TRPV1 in keratinocytes (29). In contrast, keratinocytes were reportedly resistant to vanilloid-induced TRPV1 activation and subsequent calcium influx (30).…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, TRPV1 influenced (i) synthesis of numerous pro-inflammatory mediators produced by human hair follicles [223]; (ii) cytokine and lipid production of human sebaceous gland-derived sebocytes [227]; and (iii) maturation of dendritic cells [225,234]. Furthermore, TRPV1 was found to decrease proliferation, increase apoptosis [226], and induce matrix metalloproteinase production [237][238][239] of epidermal keratinocytes; these effects may all contribute to skin aging and altered barrier functions and hence to the development of related pruritus [237,240]. In good agreement with these data, activation of TRPV1 delayed the barrier recovery after mechanical injury (tape stripping) which effect was blocked by capsazepine, a TRPV1 antagonist [241].…”
Section: The Role Of Trpv1 Expressed By Non-neuronal Cellsmentioning
confidence: 98%