A novel role for aspirin in enhancing the reprogramming function of miR‐302/367 cluster and breast tumor suppression

Rezania, Mohammad A.; Eghtedari, Azadeh; Taha, Masoumeh Fakhr; Ardekani, Ali M.; Javeri, Arash

doi:10.1002/jcb.30264

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Without changing its ability to inhibit cell growth, aspirin increases the extent of apoptosis brought on by miR-302/ 367 clusters. 83 Significantly more ARL4C is expressed in GC and ARL4C silencing caused cell cycle arrest via p53 signaling. ARL4C was significantly upregulated in GC and the upstream regulators of ARL4C are miR-302c and miR-302d, which the overexpression accelerates apoptosis in GC cells.…”

Section: Upregulation Of Mir-302/367 Family Members' Expression In Ca...mentioning

confidence: 99%

“…Aspirin promotes the EMT state, stimulates miR‐302/367‐induced BC cell reprogramming, and suppresses the expression of angiogenic and invasion markers. Without changing its ability to inhibit cell growth, aspirin increases the extent of apoptosis brought on by miR‐302/367 clusters 83 …”

Section: Relationship Between Mir‐302/367 Cluster Members and Diseasesmentioning

confidence: 99%

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The miR‐302/367 cluster: Aging, inflammation, and cancer

Zhou

Yan²,

Yan

et al. 2023

Cell Biochemistry & Function

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MicroRNAs (miRNAs) are a class of noncoding RNAs that occupy a significant role in biological processes as important regulators of intracellular homeostasis. First, we will discuss the biological genesis and functions of the miR‐302/367 cluster, including miR‐302a, miR‐302b, miR‐302c, miR‐302d, and miR‐367, as well as their roles in physiologically healthy tissues. The second section of this study reviews the progress of the miR‐302/367 cluster in the treatment of cancer, inflammation, and diseases associated with aging. This cluster's aberrant expression in cells and/or tissues exhibits similar or different effects in various diseases through molecular mechanisms such as proliferation, apoptosis, cycling, drug resistance, and invasion. This article also discusses the upstream and downstream regulatory networks of miR‐302/367 clusters and their related mechanisms. Particularly because studies on the upstream regulatory molecules of miR‐302/367 clusters, which include age‐related macular degeneration, myocardial infarction, and cancer, have become more prevalent in recent years. MiR‐302/367 cluster can be an important therapeutic target and the use of miRNAs in combination with other molecular markers may improve diagnostic or therapeutic capabilities, providing unique insights and a more dynamic view of various diseases. It is noted that miRNAs can be an important bio‐diagnostic target and offer a promising method for illness diagnosis, prevention, and treatment.

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Section: Upregulation Of Mir-302/367 Family Members' Expression In Ca...mentioning

confidence: 99%

Section: Relationship Between Mir‐302/367 Cluster Members and Diseasesmentioning

confidence: 99%

The miR‐302/367 cluster: Aging, inflammation, and cancer

Zhou

Yan²,

Yan

et al. 2023

Cell Biochemistry & Function

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“…However, more studies to investigate the correlations between miR-367 serum levels and various stages of diseases would enhance the potential of this miRNA as a biomarker. The combined tumor suppression effects of miR-367 and other miRNAs or drugs, such as aspirin (84), should also be explored in the future. However, further research is necessary to fully understand the complex regulatory mechanisms involving miR-367 in different contexts and to identify potential off-target effects of miR-367-targeted therapies.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

Muniandy,

Few,

Khoo

et al. 2023

Biomed Rep

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MicroRNA (miR)-367 has a wide range of functions in gene regulation and as such plays a critical role in cell proliferation, differentiation and development, making it an essential molecule in various physiological processes. miR-367 belongs to the miR-302/367 cluster and is located in the intronic region of human chromosome 4 on the 4q25 locus. Dysregulation of miR-367 is associated with various disease conditions, including cancer, inflammation and cardiac conditions. Moreover, miR-367 has shown promise both as a tumor suppressor and a potential diagnostic biomarker for breast, gastric and prostate cancer. The elucidation of the essential role of miR-367 in inflammation, development and cardiac diseases emphasizes its versatility in regulating various physiological processes beyond cancer biology. However, further research is necessary to fully understand the complex regulatory mechanisms involving miR-367 in different physiological and pathological contexts. In conclusion, the versatility and significance of miR-367 makes it a promising candidate for further study and in the development of new diagnostic and therapeutic strategies. Contents 1. Introduction 2. miRNA biogenesis 3. Roles of miR-367 in disease pathogenesis 4. Conclusion and future perspectives

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The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells

et al. 2023

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Background Non-steroidal anti-inflammatory drugs have been shown to inhibit the development of induced neoplasms. Our previous research demonstrated that the cytotoxicity of sulindac against melanoma cells is comparable to dacarbazine, the drug used in chemotherapy. The aim of this study was to investigate the mechanism of sulindac cytotoxicity on COLO 829 and C32 cell lines. Methods The influence of sundilac on the activity of selected enzymes of the antioxidant system (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and the content of hydrogen peroxide as well as the level of proteins initiating (p53, Bax) and inhibiting (Bcl-2) apoptosis were measured in melanoma cells. Results In melanotic melanoma cells, sulindac increased the activity of SOD and the content of H2O2 but decreased the activity of CAT and GPx. The level of p53 and Bax proteins rose but the content of Bcl-2 protein was lowered. Similar results were observed for dacarbazine. In amelanotic melanoma cells, sulindac did not cause an increase in the activity of measured enzymes or any significant changes in the level of apoptotic proteins. Conclusion The cytotoxic effect of sulindac in the COLO 829 cell line is connected to disturbed redox homeostasis by changing the activity of SOD, CAT, GPx, and level of H2O2. Sulindac also induces apoptosis by changing the ratio of the pro-apoptotic/anti-apoptotic protein. The presented studies indicate the possibility of developing target therapy against melanotic melanoma using sulindac. Graphical abstract

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A novel role for aspirin in enhancing the reprogramming function of miR‐302/367 cluster and breast tumor suppression

Cited by 5 publications

References 55 publications

The miR‐302/367 cluster: Aging, inflammation, and cancer

The miR‐302/367 cluster: Aging, inflammation, and cancer

Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

The effect of sulindac on redox homeostasis and apoptosis-related proteins in melanotic and amelanotic cells

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