A Novel Rodent Model Modifying Perioperative Temperature and Humidity during Bowel Surgery and Mimicking Laparoscopic Conditions

Glatz, Torben; Seifert, Gabriel; Holzner, Philipp; Chikhladze, Sophia; Kulemann, Birte; Sick, Olivia; Hoeppner, Jens; Hopt, Ulrich T.; Marjanović, Goran

doi:10.4236/ss.2012.37069

Cited by 3 publications

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References 32 publications

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“…The factors actually responsible for the clinically-observed beneficial effects of laparoscopic surgery are not well known [ 29 , 30 ]. Some studies show that the effects of the pneumoperitoneum on peritoneum and wound healing compare to those of a laparotomy [ 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

The degree of local inflammatory response after colonic resection depends on the surgical approach: an observational study in 61 patients

et al. 2015

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BackgroundClinical data indicate that laparoscopic surgery reduces postoperative inflammatory response and benefits patient recovery. Little is known about the mechanisms involved in reduced systemic and local inflammation and the contribution of reduced trauma to the abdominal wall and the parietal peritoneum.MethodsIncluded were 61 patients, who underwent elective colorectal resection without intraabdominal complications; 17 received a completely laparoscopic, 13 a laparoscopically- assisted procedure and 31 open surgery. Local inflammatory response was quantified by measurement of intraperitoneal leukocytes and IL-6 levels during the first 4 days after surgery.ResultsThere was no statistical difference between the groups in systemic inflammatory parameters and intraperitoneal leukocytes. Intraperitoneal interleukin-6 was significantly lower in the laparoscopic group than in the laparoscopically-assisted and open group on postoperative day 1 (26.16 versus 43.25 versus 40.83 ng/ml; p = 0.001). No difference between the groups was recorded on POD 2–4. Intraperitoneal interleukin-6 showed a correlation with duration of hospital stay on POD 1 (0.233, p = 0.036), but not on POD 2–4.Patients who developed a surgical wound infection showed higher levels of intraperitoneal interleukin-6 on postoperative day 2–4 (POD 2: 42.56 versus 30.02 ng/ml, p = 0.03), POD 3: 36.52 versus 23.62 ng/ml, p = 0.06 and POD 4: 34.43 versus 19.99 ng/ml, p = 0.046). Extraabdominal infections had no impact.ConclusionThe analysis shows an attenuated intraperitoneal inflammatory response on POD 1 in completely laparoscopically-operated patients, associated with a quicker recovery. This effect cannot be observed in patients, who underwent a laparoscopically-assisted or open procedure. Factors inflicting additional trauma to the abdominal wall and parietal peritoneum promote the intraperitoneal inflammation process.

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