A Novel Retinal Degeneration Locus Identified by Linkage and Comparative Mapping of Canine Early Retinal Degeneration

Acland, Gregory M.; Ray, Kunal; Mellersh, Cathryn S.; Langston, Amelia; Rine, Jasper; Ostrander, Elaine A.; Aguirre, Gustavo D.

doi:10.1006/geno.1999.5842

Cited by 52 publications

(18 citation statements)

References 51 publications

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“…Several canine genetic diseases have been mapped with the use of microsatellite markers (Acland et al, 1999;Jonasdottir et al, 2000). The newly identified UU42C1 marker and SNPs enabled us a fast evaluation of the DES gene as a candidate gene for DCM in the Dobermanns.…”

Section: Dobermann Family and Linkage Analysis Of The Des Markersmentioning

confidence: 99%

Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann

Stabej

Imholz

Versteeg

et al. 2004

Gene

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Section: Dobermann Family and Linkage Analysis Of The Des Markersmentioning

confidence: 99%

Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann

Stabej

Imholz

Versteeg

et al. 2004

Gene

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“…Recent studies have brought advances in understanding the genetics of breed development 15 and the availability of ever higher resolution maps [16][17][18][19][20][21] . These have led to the mapping of disease loci for a variety of diseases including metabolic disorders 22,23 , blindness [24][25][26][27][28] , cancer 29,30 neurologic disorders 31,32 , hip dysplasia 33 epilepsy 34 , as well as several morphologic traits 35,36 . In addition, the advancement of a framework for how to study complex canine traits 37 has led to deepening of our knowledge about the organization of the canine genome 38,39 and how it relates to morphological variation between breeds.…”

Section: Introductionmentioning

confidence: 99%

Finding cardiovascular disease genes in the dog

Parker

Meurs

Ostrander

2006

Journal of Veterinary Cardiology

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Recent advances in canine genomics are changing the landscape of veterinary biology, and by default, veterinary medicine. No longer are clinicians locked into traditional methods of diagnoses and therapy. Rather major advances in canine genetics and genomics from the past five years are now changing the way the veterinarian of the 21 st century practices medicine.First, the availability of a dense genome map gives canine genetics a much needed foothold in comparative medicine, allowing advances made in human and mouse genetics to be applied to companion animals. Second, the recently released 7.5x whole genome sequence of the dog is facilitating the identification of hereditary disease genes. Finally, development of genetic tools for rapid screening of families and populations at risk for inherited disease means that the cost of identifying and testing for disease loci will significantly decrease in coming years.Out of these advances will come major changes in companion animal diagnostics and therapy. Clinicians will be able to offer their clients genetic testing and counseling for a myriad of disorders. Such advances are certain to generate healthier and more long lived dogs, improving quality of life for owner and pet alike. The clinician of the 21 st century, therefore, faces incredible opportunities as well as challenges in the management of genetic disease. In this review we summarize recent findings in canine genomics and discuss their application to the study of canine cardiac health.

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“…The PRCD locus was mapped to the centromeric end of canine chromosome 9 (CFA9) in a region showing conservation of synteny with human HSA17q22 (Acland et al, 1998;Acland et al, 1999). Based on clinical similarities of the diseases, as well as chromosomal location, PRCD has been proposed as a locus homologous for RP17 and the only animal model for RP17 (Acland et al, 1998).…”

mentioning

confidence: 99%

Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

Dostal¹,

Hrdlicova²,

Horák³

2011

Vet. Med. - Czech

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Progressive rod-cone degeneration (PRCD) is a late onset autosomal photoreceptor degeneration found in canines. PRCD in canines is homologous to one form of retinitis pigmentosa (RP) found in humans and displays phenotypic similarity as well as having the identical causative mutation. The PRCD gene was mapped to the centromeric region of canine chromosome 9 (CFA9). We report here a population study of 699 dogs of the following breeds and the following frequencies of the disease-causing mutation: American Cocker Spaniel (0.09), English Cocker Spaniel (0.34), English Springer Spaniel (0.00), Welsh Springer Spaniel (0

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A Novel Retinal Degeneration Locus Identified by Linkage and Comparative Mapping of Canine Early Retinal Degeneration

Cited by 52 publications

References 51 publications

Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann

Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann

Finding cardiovascular disease genes in the dog

Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

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