A novel replicated association between FXYD6 gene and schizophrenia

Zhong, Nan; Zhang, Rui; Qiu, Chuan; Yan, Han; Valenzuela, Robert K.; Zhang, Huan; Kang, Wan-Hu; Lu, Shemin; Guo, Tingwei; Ma, Jianhua

doi:10.1016/j.bbrc.2011.01.005

Cited by 10 publications

(11 citation statements)

References 20 publications

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“…FXYD6 is expressed in the inner ear (66,67), and some studies found a relationship between FXYD6 and schizophrenia (51,359), while others have not (161,353). FXYD8 is currently annotated as a pseudogene, but its high level of conservation in primates suggests a functional role [as a protein or as a noncoding RNA ncRNA).]…”

Section: ␥-Subunitmentioning

confidence: 99%

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

Rossier

Baker

Studer

2015

Physiological Reviews

233

256

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Transcription and translation require a high concentration of potassium across the entire tree of life. The conservation of a high intracellular potassium was an absolute requirement for the evolution of life on Earth. This was achieved by the interplay of P- and V-ATPases that can set up electrochemical gradients across the cell membrane, an energetically costly process requiring the synthesis of ATP by F-ATPases. In animals, the control of an extracellular compartment was achieved by the emergence of multicellular organisms able to produce tight epithelial barriers creating a stable extracellular milieu. Finally, the adaptation to a terrestrian environment was achieved by the evolution of distinct regulatory pathways allowing salt and water conservation. In this review we emphasize the critical and dual role of Na(+)-K(+)-ATPase in the control of the ionic composition of the extracellular fluid and the renin-angiotensin-aldosterone system (RAAS) in salt and water conservation in vertebrates. The action of aldosterone on transepithelial sodium transport by activation of the epithelial sodium channel (ENaC) at the apical membrane and that of Na(+)-K(+)-ATPase at the basolateral membrane may have evolved in lungfish before the emergence of tetrapods. Finally, we discuss the implication of RAAS in the origin of the present pandemia of hypertension and its associated cardiovascular diseases.

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Section: ␥-Subunitmentioning

confidence: 99%

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

Rossier

Baker

Studer

2015

Physiological Reviews

233

256

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“…1H), consistent with the observations of Kadowaki et al (9). With regard to the association between the FXYD6 gene and schizophrenia, no consistent conclusion has been reached (17–19). Perineural invasion is a common pathway for CC metastasis and correlates with postoperative recurrence and poor prognosis (20).…”

Section: Discussionmentioning

confidence: 99%

FXYD6 is a new biomarker of cholangiocarcinoma

Chen

Sun

Hu³

et al. 2013

Oncology Letters

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Members of the FXYD domain-containing ion transport regulator protein family, including FXYD3 and FXYD5, play an important role in the pathogenesis of numerous tumors. However, the correlation between the expression of FXYD6 and tumors remains poorly understood. In the current study, the expression of FXYD6 was examined immunohistochemically in 72 cholangiocarcinoma tissues and 30 distal normal bile duct tissues matched with the tumors. The results show that the positive expression rate of FXYD6 was significantly higher in cholangiocarcinoma than that in normal bile duct tissue (69 vs. 33.3%; P=0.002). Furthermore, the positive expression rate of FXYD6 in well- and moderately-differentiated cholangiocarcinoma was clearly higher than that in poorly-differentiated and mucinous cholangiocarcinoma (85.7 vs. 40%; P=0.000). However, there was no significant correlation between the expression of FXYD6 and gender (P=0.393), age (P=0.174), histological type (P=0.123), T stage (P=0.164), lymph node metastasis (P=0.343), perineural invasion (P=0.088) and tumor location (P=0.238). The results of this study indicate that FXYD6 may be a new biomarker for cholangiocarcinoma and may be associated with a favorable prognosis in this malignant disease.

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“…(2011) [2] 576 individuals diagnosed with schizophrenia (290 males, mean age = 35.3 ± 11.6; 286 females, mean age = 32.7 ± 13.4) and 566 healthy control subjects (308 males, mean age = 29.1 ± 13.6; 258 females, mean age = 29.4 ± 13.4). All patients were diagnosed by the Psychiatry Department of the Affiliated Hospital of Xi'an Jiaotong University School of Medicine according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia.…”

Section: Gadelha Et Al (2012)mentioning

confidence: 99%

“…It is also known that GRIK2 (6q1621) and GRIA2 (4q3233) are in schizophre- Zhong et al [2] reported that the G allele of rs11544201, located in the third exon of FXYD6, is a compelling risk factor for schizophrenia in Han Chinese.…”

Section: Genes Involved In Glutamatergic Pathwaymentioning

confidence: 99%

“…Genetic factors account for more than 80% of the variance in susceptibility, and risk likely results from multiple loci of small effect [1] [2]. Supporting evidence has linked the high heritability of schizophrenia (SCZ) to a combination of relatively common alleles of small effect and to a few rare alleles with relatively large effects [3] [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

Cardoso¹,

Nascimento²,

Bernardo³

et al. 2017

Health

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Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were "Genetic markers", "Mutation", and "Schizophrenia". Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene. KeywordsSchizophrenia, Genetic Markers, Mutations, Systematic Review How to cite this paper: Cardoso, M.A.B.S., do Nascimento, T

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A novel replicated association between FXYD6 gene and schizophrenia

Cited by 10 publications

References 20 publications

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

FXYD6 is a new biomarker of cholangiocarcinoma

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

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