A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis

Sun, Yan; Yang, Zhan; Zheng, Bin; Zhang, Xinhua; Zhang, Manli; Zhao, Xueshan; Zhao, Hongyan; Suzuki, Toru; Wen, Jin‐Kun

doi:10.1161/circresaha.117.311441

Cited by 115 publications

(94 citation statements)

References 22 publications

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“…As a representative circRNA, cerebellar degeneration‐related protein 1 antisense ( CDR1as ) is the sponge of miR‐7 in the embryonic zebrafish and has been reported to be related to brain dysfunction and many cancers, such as HCC and gastric cancer . Accordingly, an increasing number of studies has revealed that the circRNA‐miRNA‐target gene regulatory network might have profound implications for understanding diseases, especially cancers . For example, a recent study shows that circ‐ZNF609 acts as an endogenous miR‐615‐5p sponge to inhibit miR‐615‐5p activity, increasing myocyte‐specific enhancer factor 2A (MEF2A) expression and ameliorating vascular endothelial dysfunction .…”

Section: Functions Of Circrnasmentioning

confidence: 99%

“…[21][22][23][24] Accordingly, an increasing number of studies has revealed that the circRNA-miRNA-target gene regulatory network might have profound implications for understanding diseases, especially cancers. 25,26 For example, a recent study shows that circ-ZNF609 acts as an endogenous miR-615-5p sponge to inhibit miR-615-5p activity, increasing myocyte-specific enhancer factor 2A (MEF2A) expression and ameliorating vascular endothelial dysfunction. 27 Zhong et al 28 found that circ-MYLK is not only related to the stage and grade of the cancer but can also work with miR-29a and relieve the suppression of target vascular endothelial growth factor A (VEGFA), a key member of the VEGFA/VEGFR2/ Ras/ERK signaling pathway.…”

Section: Mirna Sequestrationmentioning

confidence: 99%

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Circular RNAs in hepatocellular carcinoma: Functions and implications

Jiang

et al. 2018

Cancer Medicine

109

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At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with distinct properties and diverse pathophysiological functions are being increasingly delineated. CircRNAs play roles at the epigenetic, transcriptional and posttranscriptional regulatory levels. Major studies have focused on their functions as efficient microRNA sponges. The validated number of endogenous circRNAs involved in hepatocellular carcinoma (HCC) continues to increase. Altered circRNA expression is associated with HCC occurrence, invasion, and metastasis. Moreover, the aberrant expression of circRNAs is also significantly related to HCC tumor stage, size, differentiation and metastasis. Because they are exceptionally stable, highly conserved and have tissue‐specific expression patterns, some circRNAs, including hsa_circ_0004018, hsa_circ_0003570, and hsa_circ_0005075, may be potential markers for the diagnosis of HCC. We herein summarize the current knowledge of HCC‐associated circRNAs and present their implications for carcinogenesis and their potential value as diagnostic and prognostic biomarkers. Finally, we discuss the future directions of studies on HCC‐associated circRNAs.

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Section: Functions Of Circrnasmentioning

confidence: 99%

Section: Mirna Sequestrationmentioning

confidence: 99%

Circular RNAs in hepatocellular carcinoma: Functions and implications

Jiang

et al. 2018

Cancer Medicine

109

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“…RNA was synthesized by in vitro transcription as previously described by Sun et al (30). PCR primers including T7 promoter sequences of RBM5 39 UTR were designed and amplified from T24 cell line genomic DNA.…”

Section: Rna Synthesis and Biotin Pull-downmentioning

confidence: 99%

Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/β‐catenin feedback loop

et al. 2019

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RNA‐binding motif protein 5 (RBM5) acts as a tumor suppressor in various human cancers and presents with several important characteristics, such as the potentiation of apoptosis, inhibition of the cell cycle, and alternative splicing of Fas and caspase‐2 precursor mRNA. However, its role in bladder urothelial carcinoma (BUC) remains unknown. In this study, we found that RBM5 expression was significantly down‐regulated in BUC tissues when compared with the adjacent nontumor tissues. The down‐regulation of RBM5 activates ²‐catenin, which binds to the T‐cell factor/lymphocyte enhancer factor element of the miR‐432‐5p promoter and elevates the expression of miR‐432‐5p in bladder cancer cells. The up‐regulated miR‐432‐5p directly targets 3′‐UTR and depresses RBM5 expression. Thus, RBM5–miR‐432‐5p–²‐catenin forms a feedback loop in regulating bladder cancer cell apoptosis. Our findings provide evidence that the regulatory feedback loop among RBM5, miR‐432‐5p, and Wnt–²‐catenin is responsible for the progress of bladder cancer cells.—Zhang, Y.‐P., Liu, K.‐L., Wang, Y.‐X., Yang, Z., Han, Z.‐W., Lu, B.‐S., Qi, J.‐C, Yin, Y.‐W., Teng, Z.‐H., Chang, X.‐L., Li, J.‐D., Xin, H., Li, W. Down‐regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR‐432‐5p/²‐catenin feedback loop. FASEB J. 33, 10973–10985 (2019). http://www.fasebj.org

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“…Less is known regarding NRG-1-ICD, with the majority of information derived from studies in neurons. Here the authors demonstrate that NRG-1-ICD functions as a transcriptional activator in SMCs through a stable complex with Ikzf1 to induce expression of a non-coding circRNA that functions to suppress miRNA-mediated repression of αSMA 9 . Collectively, NRG-1 modulates SMC phenotype via release of both its intracellular domain and extracellular EGF-like domain.…”

mentioning

confidence: 93%

“…al 9 . assessed the role of the intracellular domain of the epidermal growth factor family member, neuregulin-1 (NRG-1-ICD) on SMC αSMA expression.…”

mentioning

confidence: 98%