A Novel Quinoline With Airway Relaxant Effects and Anti-Inflammatory Properties
Jesper Bergwik,
Jielu Liu,
Médea Padra
et al.
Abstract:Background
In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Here, we investigated the relaxant and anti-inflammatory properties in the airways of a novel quinoline (RCD405).
Methods
The airway relaxant effect of RCD405 was examined in isolated airways from humans, dogs, rats and mice. Murine models of ovalbumin (OVA)-induced allergic asthma and LPS-induced airway inflammation were used to study the effec… Show more
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