A Novel Quadraport Needle With Improved Intravitreal Drug Dispersion

Asami, Tetsu; Wong, Sui Chien; Mitchell, Patrick C.; Tokunaga, Clayton; Chen, Yi-Hao; Dang, Loan; Giblin, Frank J.; Trese, Michael T.

doi:10.1097/iae.0b013e31825a89df

Cited by 2 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Asami et al 17 described the use of a quadraport needle with four openings on the side and an occluded tip to disperse the injected fluid faster inside the vitreous. Their tests with Indian ink showed a significantly larger dispersion when using this new needle in comparison to standard needles.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] Assessment of dispersion was done by ophthalmoscopy or by dissecting the vitreous carefully out of the eye. In this study, a new method was established using an UHRCT scanner and a radio-opaque contrast agent to visualize the dispersion in a 3D-reconstructed manner without any vitreous manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…This has previously been studied either by using Indian ink or fluorescein. [15][16][17] Both colorants are easily visualized in the vitreous cavity, but it is difficult to assess or measure the real size, shape, and dispersion rate of the contrast bubble by ophthalmoscopy. Furthermore, follow-up over a period of hours or days requires in vivo tests because the cornea and lens will hinder visualization in enucleated eyes.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Intravitreally Injected Fluid Dispersion: Importance of Injection Technique

Willekens

Reyns²,

Diricx³

et al. 2017

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. The purpose of this study was to evaluate the dispersion of intravitreally injected solutions and investigate the influence of varying injection techniques.METHODS. This was a prospective study using enucleated porcine eyes and ultra-highresolution computed tomography (UHRCT) scanning to visualize iomeprol intravitreal dispersion. Sixty eyes were divided over 12 different groups according to the injection procedure: fast (2 seconds) or slow (10 seconds) injection speed and needle tip location (6-and 12-mm needle shaft insertion or premacular tip placement verified by indirect ophthalmoscopy). For each of these combinations, eyes were either injected with the combination of V20I (which is an analogue of ocriplasmin) and iomeprol or iomeprol alone. Distance to the macula and volume measurements were performed at 1, 2, 3, and 5 hours after injection.RESULTS. The measured contrast bolus volume increases slowly over time to an average of 0.70 (P ¼ 0.03), 1.04 (P ¼ 0.006), and 0.79 (P ¼ 0.0001) cm 3 5 hours after the injection for the 6-mm needle shaft insertion, 12-mm needle shaft insertion, and premacular needle tip placement, respectively. The distance to the macular marker was significantly lower for premacular needle tip placement injections compared with 6-and 12-mm needle shaft insertion depths.CONCLUSIONS. Ultra-high-resolution computed tomography with three-dimensional reconstruction offers the possibility to study the dispersion of intravitreally injected solutions in a noninvasive manner. Intravitreal premacular solution delivery is possible with an indirect ophthalmoscope-guided injection technique and significantly reduces the time to reach the posterior pole in respect to 6-and 12-mm needle insertion depths. The speed of injection does not influence dispersion significantly.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation