A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma

Wu, Zhengyuan; Chen, Leilei; Jin, Chaojie; Xu, Jing; Zhang, Xingqun; Yao, Yi

doi:10.7717/peerj.12304

Cited by 23 publications

(24 citation statements)

References 51 publications

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“…The ferroptosis-related gene signature constructed by Xu et al (2021) can predict the prognosis of melanoma patients and have a potential utility in guiding targeted therapy. Analogously, a signature consisting of four pyroptosis-associated genes will provide a promising approach to predicting survival and prognosis of melanoma patients and facilitate the personalization of treatment ( Wu et al, 2021 ). In the study of Tian et al (2021) , a robust 7 RNA binding protein signature was validated as a potential biomarker for cutaneous melanoma patients’ prognosis and immunotherapy response, contributing to advances in immunotherapy strategies ( Tian et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

Zhan

Tan

et al. 2022

Front. Pharmacol.

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Background: Melanoma is the most lethal, and one of the most aggressive forms of cutaneous malignancies, which poor response to treatment has always puzzled clinicians. As is known to all, aging and immune microenvironment are two crucial factors impacting melanoma biological progress through the tumor microenvironment (TME). However, reliable biomarkers for predicting melanoma prognosis based on aging and immune microenvironment and therapeutic efficacy of immune checkpoints remain to be determined.Methods: The aging-related genes (ARGs) were obtained from the Human Ageing Genomic Resources and immune-related genes (IRGs) were downloaded from the Immunology database as well as Analysis Portal (ImmPort) database. Next, we initially performed LASSO regression and multivariate Cox regression to identify prognostic ARGs and IRGs in the TCGA and GSE65904 datasets, and firstly constructed a novel comprehensive index of aging and immune (CIAI) signature. Finally, in vitro molecular biology experiments were performed to assess the regulatory role of CNTFR in melanoma cell lines proliferation and migration, macrophage recruitment, and M2 polarization.Results: This novel CIAI signature consisted of 7 genes, including FOXM1, TP63, ARNTL, KIR2DL4, CCL8, SEMA6A, and CNTFR, in which melanoma patients in the high-CIAI group had shorter OS, DSS, and PFI, indicating CIAI model served as an independent prognostic index. Moreover, we found the CIAI score was potentially correlated with immune scores, estimate score, immune cell infiltration level, tumor microenvironment, immunotherapy effect, and drug sensitivity. Finally, CNTFR might function as oncogenes in melanoma cell lines and the silencing of CNTFR reduced macrophage recruitment and M2 polarization.Conclusion: In this study, we have first presented a novel prognostic CIAI model applied to assess immune checkpoint therapy and the efficacy of conventional chemotherapy agents in melanoma patients. Thus providing a new insight for combating melanoma.

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Section: Discussionmentioning

confidence: 99%

A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

Zhan

Tan

et al. 2022

Front. Pharmacol.

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“…Moreover, Spearman correlation analysis was conducted to measure the relationship between the risk score and tumor stemness. 21 …”

Section: Methodsmentioning

confidence: 99%

“…The results were considered as statistically significant differences while the p < 0.05. Moreover, Spearman correlation analysis was conducted to measure the relationship between the risk score and tumor stemness 21 …”

Section: Methodsmentioning

confidence: 99%

Construction of a necroptosis‐related lncRNA signature to predict the prognosis and immune microenvironment of head and neck squamous cell carcinoma

Huang

Teh

et al. 2022

Clinical Laboratory Analysis

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Background Previous studies have determined that necroptosis‐related genes are potential biomarkers in head and neck squamous cell carcinoma (HNSCC). Herein, we established a novel risk model based on necroptosis‐related lncRNAs (nrlncRNAs) to predict the prognosis of HNSCC patients. Methods Transcriptome and related information were obtained from TCGA database, and an nrlncRNA signature was established based on univariate Cox analysis and least absolute shrinkage and selection operator Cox regression. Kaplan–Meier analysis and time‐dependent receiver operating characteristic (ROC) analysis were used to evaluate the model, and a nomogram for survival prediction was established. Gene set enrichment analysis, immune analysis, drug sensitivity analysis, correlation with N6‐methylandenosin (m6A), and tumor stemness analysis were performed. Furthermore, the entire set was divided into two clusters for further discussion. Results A novel signature was established with six nrlncRNAs. The areas under the ROC curves (AUCs) for 1‐, 3‐, and 5‐year overall survival (OS) were 0.699, 0.686, and 0.645, respectively. Patients in low‐risk group and cluster 2 had a better prognosis, more immune cell infiltration, higher immune function activity, and higher immune scores; however, patients in high‐risk group and cluster 1 were more sensitive to chemotherapy. Moreover, the risk score had negative correlation with m6A‐related gene expression and tumor stemness. Conclusion According to this study, we constructed a novel signature with nrlncRNA pairs to predict the survival of HNSCC patients and guide immunotherapy and chemotherapy. This may possibly promote the development of individualized and precise treatment for HNSCC patients.

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“…gov/ gds). Thirty-three pyroptosis-related genes were obtained from a previous publication (Additional file 1: Table S2) [14].…”

Section: Datasets and Sourcementioning

confidence: 99%

Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer

Liu

Shen

et al. 2022

J Transl Med

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Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in tumorigenesis and development. However, compressive analysis and biological regulation of pyroptosis genes are lacking in cancers. Methods Using data from The Cancer Genome Atlas, we established a score level model to quantify the pyroptosis level in cancer. Multiomics bioinformatic analyses were performed to assess pyroptosis-related molecular features and the effect of pyroptosis on immunotherapy in cancer. Results In the present study, we performed a comprehensive analysis of pyroptosis and its regulator genes in cancers. Most pyroptosis genes were aberrantly expressed in different types of cancer, attributed to the CAN frequency and differences in DNA methylation levels. We established a pyroptosis level model and found that pyroptosis had dual roles across cancers, while the pyroptosis levels were different among multiple cancers and were significantly associated with clinical prognosis. The dual role of pyroptosis was also shown to affect immunotherapeutic efficacy in several cancers. Multiple pyroptosis genes showed close associations with drug sensitivity across cancers and may be considered therapeutic targets in cancer. Conclusions Our comprehensive analyses provide new insight into the functions of pyroptosis in the initiation, development, progression and treatment of cancers, suggesting corresponding prognostic and therapeutic utility.

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A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma

Cited by 23 publications

References 51 publications

A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

A combined aging and immune prognostic signature predict prognosis and responsiveness to immunotherapy in melanoma

Construction of a necroptosis‐related lncRNA signature to predict the prognosis and immune microenvironment of head and neck squamous cell carcinoma

Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer

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