A novel pulsed electromagnetic field promotes distraction osteogenesis via enhancing osteogenesis and angiogenesis in a rat model

Li, Yucong; Pan, Qi; Zhang, Nianli; Wang, Bin; Yang, Zhengmeng; Ryaby, James T.; Waldorff, Erik I.; Lee, Wayne; Li, Gang

doi:10.1016/j.jot.2020.10.007

Cited by 17 publications

(27 citation statements)

References 33 publications

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“…Gossling HR et al [ 13 ] demonstrated in 1992 that the activation of body magnetic fields in different traumatic pathologies could be as effective as surgical interventions. Li Y et al [ 14 ] reached the same conclusions in 2020. Both Gossling et al and Li et al concluded that the treatment of non-healing bone fractures with electromagnetic fields has proven more successful than the traditional approach.…”

Section: Discussionmentioning

confidence: 55%

“…Biologically, bioelectrical signals provide pathways to restore normal functioning and homeostasis after injury [ 9 ]. It has been demonstrated that magnetic fields positively influence human tissue and result in several therapeutic effects, such as pain relief, bone regeneration, muscle regeneration, improved nerve functioning, and improvement in tissue vascularization [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Additionally, animal studies have identified increased vascularization in rabbits when exposed to static magnetic fields (SMFs) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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The Direct Effect of Magnetic Tape® on Pain and Lower-Extremity Blood Flow in Subjects with Low-Back Pain: A Randomized Clinical Trial

Selva-Sarzo

Fernández-Carnero

Sillevis

et al. 2021

Sensors

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Low-back pain has a high impact on the world population, and solutions are in demand. The behavior of specific physiological processes has been modified using magnetic fields, whether for pain relief, bone consolidation, or improvement of vascularization. The use of tape with magnetic properties could help in these cases. A double-blind randomized clinical trial was designed to use Magnetic Tape® versus placebo Kinesio tape. Blood flow variables were evaluated using pulsed power Doppler ultrasound. Resistance index, pulsatility index, systolic velocity, and diastolic velocity were measured. The pressure pain threshold was measured using algometry in 22 subjects. The results reveal significant differences between the groups for the pulsation index variable (8.06 [5.16, 20.16] in Magnetic Tape® versus 5.50 [4.56, 6.64] in Kinesio tape) and lower (0.98 [0.92, 1.02] for Magnetic Tape® versus 0.99 [0.95, 1.01] for Kinesio tape) in the resistance index variable. The pressure pain threshold variable presented significant differences at multiple levels. The application of Magnetic Tape® causes immediate effects on blood flow and pain and could be a technique of choice for pain modulation. Further studies would be necessary.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The Direct Effect of Magnetic Tape® on Pain and Lower-Extremity Blood Flow in Subjects with Low-Back Pain: A Randomized Clinical Trial

Selva-Sarzo

Fernández-Carnero

Sillevis

et al. 2021

Sensors

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“…Physical stimulation : Physical therapies including low-intensity pulsed ultrasound (LIPUS) [ [37] , [38] , [39] ], low-level laser (LLL) [ 40 , 41 ], electrical stimulation (ES) [ 42 , 43 ], and pulsed electromagnetic field stimulation [ 44 , 45 ] had been investigated to accelerate bone formation in the consolidation phase during DO. Shimazaki et al.…”

Section: Enhancement Of Bone Formation In Domentioning

confidence: 99%

“…Li et al. reported that the pulsed electromagnetic field could reduce the healing time of regenerated bone in a rabbit DO model [ 44 ]. However, the mechanisms and efficiency of the physical stimulation methods in accelerating DO bone formation still need further elucidation.…”

Section: Enhancement Of Bone Formation In Domentioning

confidence: 99%

Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals

Pan

et al. 2021

Journal of Orthopaedic Translation

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Background Distraction osteogenesis (DO) is a functional tissue engineering approach that applies gradual mechanical traction on the bone tissues after osteotomy to stimulate bone regeneration. However, DO still has disadvantages that limit its clinical use, including long treatment duration Methods Review the current methods of promoting bone formation and consolidation in DO with particular interest on biometal. Results Numerous approaches, including physical therapy, gene therapy, growth factor-based therapy, stem-cell-based therapy, and improved distraction devices, have been explored to reduce the DO treatment duration with some success. Nevertheless, no approach to date is widely accepted in clinical practice due to various reasons, such as high expense, short biologic half-life, and lack of effective delivery methods. Biometals, including calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), manganese (Mn), and cobalt (Co) have attracted attention in bone regeneration attributed to their biodegradability and bioactive components released during in vivo degradation. Conclusion This review summarizes the current therapies accelerating bone formation in DO and the beneficial role of biometals in bone regeneration, particularly focusing on the use of biometal Mg and its alloy in promoting bone formation in DO. Translational potential: The potential clinical applications using Mg-based devices to accelerate DO are promising. Mg stimulates expression of multiple intrinsic biological factors and the development of Mg as an implantable component in DO may be used to argument bone formation and consolidation in DO.

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“…19-26 It is now clear that PEMF promotes bone-healing by enhancing osteogenesis 27,28 and angiogenesis. 29,30 The promoting effects of PEMF are signal-specific and dependent. 14,15 Therefore, careful investigation of a specific PEMF signal should be conducted before it may be clinically applied.…”

Section: Introductionmentioning

confidence: 99%

High slew rate pulsed electromagnetic field enhances bone consolidation and shortens daily treatment duration in distraction osteogenesis

Yang

Wang

Zhang

et al. 2021

Bone & Joint Research

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Aims Distraction osteogenesis (DO) is a useful orthopaedic procedure employed to lengthen and reshape bones by stimulating bone formation through controlled slow stretching force. Despite its promising applications, difficulties are still encountered. Our previous study demonstrated that pulsed electromagnetic field (PEMF) treatment significantly enhances bone mineralization and neovascularization, suggesting its potential application. The current study compared a new, high slew rate (HSR) PEMF signal, with different treatment durations, with the standard Food and Drug Administration (FDA)-approved signal, to determine if HSR PEMF is a better alternative for bone formation augmentation. Methods The effects of a HSR PEMF signal with three daily treatment durations (0.5, one, and three hours/day) were investigated in an established rat DO model with comparison of an FDA-approved classic signal (three hrs/day). PEMF treatments were applied to the rats daily for 35 days, starting from the distraction phase until termination. Radiography, micro-CT (μCT), biomechanical tests, and histological examinations were employed to evaluate the quality of bone formation. Results All rats tolerated the treatment well and no obvious adverse effects were found. By comparison, the HSR signal (three hrs/day) treatment group achieved the best healing outcome, in that endochondral ossification and bone consolidation were enhanced. In addition, HSR signal treatment (one one hr/day) had similar effects to treatment using the classic signal (three three hrs/day), indicating that treatment duration could be significantly shortened with the HSR signal. Conclusion HSR signal may significantly enhance bone formation and shorten daily treatment duration in DO, making it a potential candidate for a new clinical protocol for patients undergoing DO treatments. Cite this article: Bone Joint Res 2021;10(12):767–779.

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A novel pulsed electromagnetic field promotes distraction osteogenesis via enhancing osteogenesis and angiogenesis in a rat model

Cited by 17 publications

References 33 publications

The Direct Effect of Magnetic Tape® on Pain and Lower-Extremity Blood Flow in Subjects with Low-Back Pain: A Randomized Clinical Trial

The Direct Effect of Magnetic Tape® on Pain and Lower-Extremity Blood Flow in Subjects with Low-Back Pain: A Randomized Clinical Trial

Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals

High slew rate pulsed electromagnetic field enhances bone consolidation and shortens daily treatment duration in distraction osteogenesis

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