A novel protein encoded by circKANSL1L regulates skeletal myogenesis via the Akt-FoxO3 signaling axis

Lin, Zekun; Xie, Fang; He, Xiao; Wang, Jing; Luo, Junyi; Chen, Ting; Jiang, Qingyan; Xi, Qianyun; Zhang, Yongliang; Sun, Jiajie

doi:10.1016/j.ijbiomac.2023.128609

Cited by 2 publications

(1 citation statement)

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“…Unlike linear RNAs, circRNAs exhibit greater structural stability and conservation. They serve various functions, including acting as molecular sponges for miRNAs, modulating linear RNA expression, binding to proteins, encoding proteins, and giving rise to pseudogenes, implicating them in a wide array of biological processes [ 14 , 15 , 16 , 17 ]. For example, circRNAs have been found to play roles in fat deposition and metabolism processes in chicken liver [ 18 ] and to contribute to liver lipid metabolism, transport, and deposition in pig liver [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of circRNA–miRNA–mRNA Interactions in the Regulation of Goose Liver Development

Liu,

Li,

et al. 2024

Animals

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The liver, a crucial metabolic organ in animals, is responsible for the synthesis, breakdown, and transport of lipids. However, the regulatory mechanisms involving both coding and noncoding RNAs that oversee the development of the goose liver remain elusive. This study aimed to fill this knowledge gap by conducting RNA-seq to profile the expression of circular RNAs (circRNAs) and microRNAs (miRNAs) during goose liver development. We analyzed circRNAs in liver samples from Sichuan white geese at three developmental stages: posthatching day 0, 10 weeks (fast growth stage), and 30 weeks (sexual maturation stage). Our findings revealed 11,079 circRNAs and 994 miRNAs, among which the differentially expressed circRNAs and miRNAs were significantly enriched in pathways such as fatty acid biosynthesis, degradation, and metabolism. Further analysis of the target genes of the differentially expressed miRNAs revealed enrichment in pathways related to fatty acid biosynthesis, metabolism, PPAR signaling, DNA replication, and the cell cycle. We also established circRNA–miRNA–mRNA regulatory networks, identifying key regulatory factors and miRNAs. In conclusion, our study offers valuable insights into the complex interplay of circRNA–miRNA–mRNA interactions during goose liver development, and illuminates the molecular pathways that regulate this vital life function.

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