A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives

Sarzani, Riccardo; Dessı̀-Fulgheri, Paolo; Salvi, F.; Serenelli, Massimiliano; Spagnolo, Diego; Cola, Giovanna; Pupita, Mauro; Giantomassi, Laura; Rappelli, A

doi:10.1097/00004872-199917090-00010

Cited by 82 publications

(81 citation statements)

References 12 publications

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“…1,4,[13][14][15] These associations might be influenced by multiple gene-environment interactions, age-dependent gene expression changes, and selection criteria of cases and controls.…”

Section: Discussionmentioning

confidence: 99%

Aldosterone synthase alleles and cardiovascular phenotype in young adults

et al. 2003

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The C(À344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/ phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where interactions among genes, gene-environment, and acquired ageing-related organ damage are reduced. Anthropometric measurements, blood pressure, heart rate, left ventricular variables (by echocardiography), and carotid artery wall intimal-media thickness (by high-resolution sonography and digitalized morphometry) were taken in 420 white Caucasian students (mean age 23.5 years, s.d. 2.5 years). CYP11B2 alleles were detected by genomic polymerase chain reaction followed by digestion. Taking into account the three possible models of inheritance, we found no differences in the considered variables, except for an independent effect of the C(À344) allele on SBP in males (TT 125.6 (1.6), TC 128.4 (1.2) and CC 130.5 (2.2), mmHg, media (ES), P ¼ 0.03), and on interventricular septum thickness in diastole in females (CC 6.98 (0.12) vs TT 6.87 (0.09) and TC 6.87 (0.07), mmHg, Po0.01), in the codominant model. In conclusion, the CYP11B2 C(À344)T polymorphism appears to have a slight role in the cardiovascular phenotype of young healthy adults, even if these genotype/phenotype relationships might change with ageing.

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“…1,4,[13][14][15] These associations might be influenced by multiple gene-environment interactions, age-dependent gene expression changes, and selection criteria of cases and controls.…”

Section: Discussionmentioning

confidence: 99%

Aldosterone synthase alleles and cardiovascular phenotype in young adults

et al. 2003

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“…An A-to-C substitution polymorphism at position 55 upstream has been found, and individuals with the C/C genotype have been reported to have significantly lower ANP levels and higher systolic blood pressure [44]. Recently we discovered a six-nucleotide repeat polymorphism located 4 base pairs (bp) upstream of the major transcriptional initiation site of the NPRC (Fig.…”

Section: Natriuretic Peptide Receptorsmentioning

confidence: 99%

The Genetic Contribution of the Natriuretic Peptide System to Cardiovascular Diseases

Nakayama

2005

Endocr J

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Abstract. Three types of natriuretic peptides (NP) have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The NP family elicits a number of vascular, renal and endocrine effects that help to maintain blood pressure and extracellular fluid volume. These effects are mediated by the specific binding of NP to cell surface receptors that have been characterized, purified and cloned from cells of the vasculature, kidney, adrenal gland and brain. There are 3 subtypes of NP receptors: type A natriuretic peptide receptor (NPRA), type B natriuretic peptide receptor (NPRB), and type C natriuretic peptide receptor (NPRC). All 3 subtypes affect cellular second messenger activity. NPRA and NPRB are guanylyl cyclase receptors, and their activation increases cGMP levels. Activation of NPRC results in inhibition of adenylyl cyclase activity. Human NPRA has a high structural homology with human NPRB, and contains a highly-conserved guanylyl cyclase domain. ANP and BNP bind primarily to NPRA, which is found in the vasculature, causing vasodilation and inhibition of vascular smooth muscle cell proliferation. The present paper contains a review of NPs and their receptors and the genetic contribution of the NP system to cardiovascular diseases such as essential hypertension and myocardial infarction.

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“…These shifts, which could be due to enhanced activity of the NPRC, could well tend to elevate BP. 30 An hypothesis on the pathogenesis of hypertension in obese patients considers that the development of hypertension in genetically predisposed obese individuals may be triggered by an adaptive response to excess carbohydrate and fat intake which conveys a positive energy balance and an increase in plasma insulin. The latter change would elevate the activity of the central sympathetic nervous system, and thus increase cardiac activity and result in an increase in BP.…”

Section: Pathogenesis Of Hypertension In Obese Subjectsmentioning

confidence: 99%

Hypertension and obesity

Díaz

2002

J Hum Hypertens

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Obesity, as defined by bodily weight (body weight) and by bodily conformation-derived variables, accompanies hypertension in many patients. Both conditions are independent cardiovascular risk factors. In a formal survey carried out in the adult general population of Uruguay (LATIR Study, 575 adult and elderly subjects of whom 41.6% were males), we found the prevalence of hypertension to be 28.5% (95% CI: 24.9-32.4%) and that 74.4% of hypertensive individuals had a body mass index (BMI) higher than 25 kg/m 2 (95% CI: 67.0-80.8%). This association between obesity and hypertension forms part of a broader relationship between body weight and blood pressure (BP). In the general population, BP bears a positive linear correlation with BMI and waist-to-hip ratio over the continuous ranges of normal and unfavourable values of these three variables (r = 0.42, P Ͻ 0.001 for the correlation between BMI and mean BP, LATIR Study). Patients who present hyperten-

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A novel promoter variant of the natriuretic peptide clearance receptor gene is associated with lower atrial natriuretic peptide and higher blood pressure in obese hypertensives

Cited by 82 publications

References 12 publications

Aldosterone synthase alleles and cardiovascular phenotype in young adults

Aldosterone synthase alleles and cardiovascular phenotype in young adults

The Genetic Contribution of the Natriuretic Peptide System to Cardiovascular Diseases

Hypertension and obesity

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