A novel prognostic model based on three clinic-related miRNAs for prostate cancer

Abstract

BackgroundProstate cancer (PCa) is the second most common malignant tumor in men worldwide. MiRNAs have been reported to play significant roles in prognosis prediction for patients with malignant tumors.MethodsThe survival-related miRNAs (sDMIRs) were identified by Cox regression analysis. A risk score model (RSM) was established based on three sDMIRs. The expression levels of sDMIRs in cell lines and clinical samples were detected via quantitative polymerase chain reaction. The correlations between sDMIRs and clinicopathological characteristics of PCa patients were evaluated using the chi-square test and Fisher's exact probability method.ResultsFour sDMIRs were remarkably related to the prognosis of PCa patients based on univariate Cox analysis, of which miR-10a-5p, miR-20a-5p, and miR-508-3p were used to establish the RSM. The OS in the low-risk group was better than that in the high-risk group. In the verification of various prostate cell lines and clinical samples from 162 PCa patients, the prominently higher expression of miR-10a-5p and miR-20a-5p and lower expression of miR-508-3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. Besides, the higher expression of miR-20a-5p and miR-10a-5p was significantly correlated to the higher level of PSA, Gleason score, more advanced T-stage, and distant metastasis status.ConclusionWe identify and validate the clinical significance of three sDMIRs and establish a verified RSM to evaluate the prognosis for PCa patients. The findings not only provide a reliable tool for clinical decision-makers to evaluate patients' prognosis but also offer a novel perspective into the field of biomarker identification.

The value of a group of serum miRNAs in screening prostate cancer

“…MiR-10a-5p can also in uence prostate cancer development by regulating the BDNF / TRKB pathway (30). It has also been shown that high levels of mir in tissues are associated with the prognosis of PC (31). These studies have demonstrated the important role of miR-10a-5p in PC.…”

The value of a panel of circulating microRNAs in screening prostate cancer

“…MiR-10a-5p can also influence PCa development by regulating the brain-derived neurotrophic factor (BDNF)/TRKB pathway ( 39 ). It has also been shown that high levels of mir in tissues are associated with the prognosis of PCa ( 40 ). These studies have demonstrated the important role of miR-10a-5p in PCa.…”