A novel prognostic inflammation score predicts outcomes in patients with ovarian cancer

Wang, Yuanqiu; Jin, Chu; Zheng, Hao; Zhou, Kai; Shi, Bingjie; Zhang, Qian; Zheng, Fangfang; Lin, Feng

doi:10.1016/j.cca.2016.03.013

Cited by 39 publications

(51 citation statements)

References 37 publications

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“…However, the prognostic significance of NLR and PLR in ovarian cancer remains controversial [12–15]. Recently, PLRs have been used as an independent predictor of survival in patients with ovarian cancer [13].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, PLRs have been used as an independent predictor of survival in patients with ovarian cancer [13]. In addition, the use of NLR could not only apply as a prognostic marker, but also aid in treatment choices in ovarian cancer [12,14,16,17]. Furthermore, variation in the reported NLR threshold used to assign patients to high-risk or low-risk cohorts complicates the application of a single NLR determination for patient’s prognostic prediction.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, hypoalbuminaemia has been used as an independent predictor of survival in ovarian cancer patients [8]. Furthermore, an integrated indicator based on hypoalbuminaemia and NLR was applied for the prediction of poor survival adjusted for other clinicopathologic characteristics in ovarian cancer [12]. Consistently with previous studies, we found out that hypoalbuminaemia alone acted as an independent predictor of PFS, while the systemic inflammation scoring consisting of hypoalbuminaemia and NLR used as an independent factor for predicting PFS and OS in clear cell ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Zhang

Lü

Lu³

et al. 2017

PLoS ONE

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Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell’s concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS (P = 0.006) and OS (P = 0.019). The SIS had a good discrimination ability for the predictive PFS (c-index = 0.712) and OS (c-index = 0.722). We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Zhang

Lü

Lu³

et al. 2017

PLoS ONE

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“…Malnutrition of cancer patients including EOC patients is common and is related to poor survival. Thus, cachexia is regarded as an important prognostic factor for EOC [152,153]. Cachexia can be estimated by measuring plasma albumin levels [152,153], indicating that plasma albumin concentration can significantly vary depending on the progression of EOC.…”

Section: Potential Tf-fviia-driven Inflammatory Responses Within Hmentioning

confidence: 99%

“…Thus, cachexia is regarded as an important prognostic factor for EOC [152,153]. Cachexia can be estimated by measuring plasma albumin levels [152,153], indicating that plasma albumin concentration can significantly vary depending on the progression of EOC. Hypoxia associated with an insufficient supply of serum lipid (LCFA–albumin complex) causes synergistic activation of the ICAM1 gene to promote CCC cell survival activity [34].…”

Section: Potential Tf-fviia-driven Inflammatory Responses Within Hmentioning

confidence: 99%

Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O2 and Plasma Supply

Koizume¹,

Miyagi²

2017

IJMS

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Tissue factor (TF) is a cell surface receptor for coagulation factor VII (fVII). The TF-activated fVII (fVIIa) complex is an essential initiator of the extrinsic blood coagulation process. Interactions between cancer cells and immune cells via coagulation factors and adhesion molecules can promote progression of cancer, including epithelial ovarian cancer (EOC). This process is not necessarily advantageous, as tumor tissues generally undergo hypoxia due to aberrant vasculature, followed by reduced access to plasma components such as coagulation factors. However, hypoxia can activate TF expression. Expression of fVII, intercellular adhesion molecule-1 (ICAM-1), and multiple pro-inflammatory cytokines can be synergistically induced in EOC cells in response to hypoxia along with serum deprivation. Thus, pro-inflammatory responses associated with the TF-fVIIa–ICAM-1 interaction are expected within hypoxic tissues. Tumor tissue consists of multiple components such as stromal cells, interstitial fluid, albumin, and other micro-factors such as proton and metal ions. These factors, together with metabolism reprogramming in response to hypoxia and followed by functional modification of TF, may contribute to coagulation factor-driven inflammatory responses in EOC tissues. The aim of this review was to describe potential coagulation factor-driven inflammatory responses in hypoxic EOC tissues. Arguments were extended to clinical issues targeting this characteristic tumor environment.

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The Memorial Sloan Kettering Prognostic Score: Correlation with survival in patients with advanced gastric cancer

Wan,

Ding,

et al. 2023

Cancer Medicine

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BackgroundNotwithstanding that the past decade has witnessed unprecedented medical progress, gastric cancer (GC) remains a leading cause of cancer death, highlighting the need for effective prognostic markers. The Memorial Sloan Kettering Prognostic Score (MPS) has been validated as a valuable prognostic tool for patients with metastatic pancreatic adenocarcinoma (mPDAC). This study aimed to assess the prognostic value of the MPS in advanced GC.MethodsData from 367 patients were analyzed in the present study. The MPS for each patient was calculated based on the sum of scores based on the neutrophil‐to‐lymphocyte ratio and serum albumin levels. Multivariate analyses were performed to identify the independent clinicopathological parameters associated with overall survival (OS). Further subgroup analyses based on clinicopathological features were conducted.ResultsPatients with MPS 0 (n = 161), MPS 1 (n = 158), and MPS 2 (n = 48) exhibited significantly different OS, with a median survival duration of 20.7 (95%CI: 12.2–29.2), 14.9 (95%CI: 12.5–17.3), and 12.7 (95%CI: 9.3–16.0) months, respectively (p < 0.001). Significant differences in survival were observed among different groups of patients receiving chemotherapy (18.5 months vs. 14.7 months vs. 11.0 months, p = 0.03) or the subgroup receiving chemotherapy plus immunotherapy as first‐line treatment (32.6 months vs. 17.7 months vs. 12.7 months, p = 0.02). The MPS was identified as an independent prognostic factor in multivariate analysis. During subgroup analyses, MPS‐low (MPS 0) was consistently associated with a better prognosis than MPS‐high (MPS 1 or 2).ConclusionsMPS is a practical, simple, and useful prognostic tool for patients with advanced GC. Further studies are warranted to validate its prognostic value in advanced GC.

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A novel prognostic inflammation score predicts outcomes in patients with ovarian cancer

Cited by 39 publications

References 37 publications

Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma

Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O2 and Plasma Supply

The Memorial Sloan Kettering Prognostic Score: Correlation with survival in patients with advanced gastric cancer

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