A novel prognostic biomarker for cutaneous malignant melanoma: red cell distribution width (RDW) to lymphocyte ratio

Abstract

It is well-known that inflammation plays a significant role in cancer formation and prognosis. Both lymphocyte count and red cell distribution width (RDW) has been used to predict prognosis in various cancers as an indicator of inflammation. Yet, the role of RDW-lymphocyte ratio (RLR) in determining prognosis is still unknown. We aimed to determine the prognostic role of RLR in cutaneous malignant melanoma (MM). One hundred fifteen patients with MM were included in the study retrospectively. The relationship of the clinical-pathological data with overall survival (OS) and progression-free survival (PFS) was analyzed using Kaplan-Meier curves. The cut-off values of neutrophil to lymphocyte ratio, systemic immuneinflammation index (SII), prognostic nutritional index (PNI) and RLR were determined as 2, 487, 51.5 and 6.52, respectively. OS was significantly longer in the low SII, high PNI, low RLR group, while PFS was longer in groups with high PNI and low RLR. In univariate analysis, it was determined that PFS was significantly correlated with Eastern Cooperative Oncology Group (ECOG) performance, TNM stage, PNI and RLR. Moreover, in univariate analysis, a significant correlation was determined between OS and age, ECOG performance, TNM stage, adjuvant interferon, SII, PNI and RLR. In multivariate analysis, ECOG performance, TNM stage and RLR were determined as independent prognostic factors for PFS, while TNM stage and RLR were found to be independent prognostic factors for OS. RLR could be a novel prognostic marker for both PFS and OS in patients with cutaneous MM.

Red Cell Distribution Width-to-High-Density Lipoprotein Cholesterol Ratio (RHR): A Promising Novel Predictor for Preoperative Deep Vein Thrombosis in Geriatric Patients with Hip Fracture

“…For RDW, RDW-to-lymphocyte ratio was confirmed to be independently associated with the prognosis of cutaneous malignant melanoma, and RDW-to-platelet ratio can be used for the early prediction of cirrhosis and hepatic fibrosis in patients with chronic hepatitis B. 34 , 35 For HDL-C, neutrophils-to-HDL-C ratio had been confirmed as a significant predictor of severe coronary artery stenosis, and triglyceride-to-HDL-C ratio was employed to identify insulin resistance and cardiometabolic risk among children with obesity. 36 , 37 Different from previous studies, the current one was the first attempt to use RDW-to-HDL-C ratio and fully demonstrate its excellent thrombotic predictive value in the field of trauma.…”

Karbon monoksit zehirlenmesinde troponin yükselmesini öngörmede sistemik immün-inflamasyon indeksi ve eritrosit dağılım genişliği-lenfosit oranının tanısal değeri

“…Wu et al demonstrated high sensitivity and specificity of RLR in predicting hepatic impairment in patients with hepatitis E virüs 19 . Hannarici et al discovered the role of RLR as a prognostic marker in cutaneous malignant melanoma 20 . We found that RLR can predict troponin elevation in patients with COP.…”

Use of laboratory hematology data in melanoma research: comments on “A novel prognostic biomarker for cutaneous malignant melanoma: red cell distribution width (RDW) to lymphocyte ratio” Melanoma Res 2021; 31:566-574.

“…I read with interest the article entitled 'A novel prognostic biomarker for cutaneous malignant melanoma: red cell distribution width (RDW) to lymphocyte ratio' by Hannarici et al [1] which was recently published in Melanoma Research. I thank the authors for their thoughtful contribution to expanding literature that explores the use of complete blood cell count (CBC) analytes in risk stratification and outcome prediction in melanoma and many other neoplastic and non-neoplastic diseases.…”

“…Although analytical and preanalytical variables may be particularly problematic for studies that pool data from multiple institutions, preanalytical issues may cause difficulty even in studies conducted in a single institution, because specimen handling conditions may vary among inpatient, outpatient and satellite clinic specimen collection, for example. Although I note that the specimens collected by Hannarici et al [1] originated in a single outpatient environment, it would be important to readers to take into account these potential sources of bias in using the RDW to lymphocyte ratio in clinical practice.…”

“…Although I note that the specimens collected by Hannarici et al . [1] originated in a single outpatient environment, it would be important to readers to take into account these potential sources of bias in using the RDW to lymphocyte ratio in clinical practice.…”