A novel prediction equation of resting energy expenditure for Japanese septic patients

Takemae, Akihito; Takazawa, Tomonori; Kamiyama, Jiro; Kanamoto, Masafumi; Tobe, Masaru; Hara, Hiroshi; Kunimoto, Fumio; Saito, Shigeru

doi:10.1016/j.jcrc.2020.01.021

Cited by 3 publications

(8 citation statements)

References 36 publications

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“…The purpose of some studies that assessed EE was to evaluate energy metabolism in patients with sepsis (and possibly its relationship with disease severity and prognosis), compare the results obtained by various methods or develop new predictive equations. Nine such studies were identified [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. In other studies, EE was measured to assess its change under the influence of the interventions tested–hyperinsulinaemic clamp [ 61 , 62 , 63 ], liberation from mechanical ventilation [ 64 ], continuous renal replacement therapy [ 65 ], early exercise [ 66 ], or cardiac selective beta adrenergic [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 14 studies compared in Table 2 , RQ was given in eight, of which six presented the data in the form of mean and standard deviation. The mean RQ presented in the studies ranged from 0.76 ± 0.12 [ 52 ] to 0.99 ± 0.06 [ 67 ] ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…The most frequently occurring limitations included the small size of the study group ( n = 3) (the groups in the study had 16, 27, and 62 patients) [ 54 , 55 , 65 ], as well as equal mention that the study was conducted at a single centre [ 53 , 55 , 65 ]. Doubts were also expressed as to whether one measurement per day, most often obtained at a fixed time for all patients, would be representative of daily EE [ 52 , 54 , 55 ]. In two works, it was noted that patients admitted to ICU may be at various stages of the disease, which could have initially progressed e.g.…”

Section: Resultsmentioning

confidence: 99%

“…when the patient was in another ward and their condition was not severe enough to qualify them for treatment in ICU [ 55 , 64 ]. Some of the other limitations mentioned included: no protocol to control patient nutrition [ 52 ], EE measurement only on admission [ 53 ], difficulties in obtaining steady state [ 54 ], variability in sedation management and body mass [ 64 ], and no assessment of the impact of medical procedures on EE [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

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Methodological Aspects of Indirect Calorimetry in Patients with Sepsis—Possibilities and Limitations

Wasyluk

Zwolak

Jonckheer³

et al. 2022

Nutrients

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The aim of the review was to analyse the challenges of using indirect calorimetry in patients with sepsis, including the limitations of this method. A systematic review of the literature was carried out. The analysis concerned the methodology and presentation of research results. In most studies assessing energy expenditure, energy expenditure was expressed in kcal per day (n = 9) and as the mean and standard deviation (n = 7). Most authors provided a detailed measurement protocol, including measurement duration (n = 10) and device calibration information (n = 7). Ten papers provided information on the day of hospitalisation when the measurements were obtained, nine on patient nutrition, and twelve on the criteria for inclusion and exclusion of participants from the study. Small study group sizes and study at a single centre were among the most cited limitations. Studies assessing energy expenditure in patients with sepsis by indirect calorimetry differ in the methodology and presentation of results, and their collective analysis is difficult. A meta-analysis of the results could enable multi-site and large patient evaluation. Standardisation of protocols and presentation of all collected data would enable their meta-analysis, which would help to achieve greater knowledge about metabolism in sepsis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Methodological Aspects of Indirect Calorimetry in Patients with Sepsis—Possibilities and Limitations

Wasyluk

Zwolak

Jonckheer³

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…S1). First, the values considered out of the physiological range (VCO 2 < 70 mL/min or > 800 mL/min; VO 2 < 100 mL/min or > 1000 mL/min; and RQ < 0.67 or > 1.3) were excluded [ 21 – 23 ]. Second, the average values every 5 min (24 points for 2 h) in each of VCO 2 , VO 2 , and RQ were obtained.…”

Section: Methodsmentioning

confidence: 99%

Changes in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis

et al. 2021

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Background Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO2) and oxygen extraction (VO2) evaluated using indirect calorimetry (IC) might provide additional information to understand the dynamic metabolic changes in sepsis. Methods Adult patients with sepsis who required mechanical ventilation in the intensive care unit (ICU) of our hospital between September 2019 and March 2020 were prospectively enrolled. Sepsis was diagnosed according to Sepsis-3. Continuous measurement of VCO2 and VO2 using IC for 2 h was conducted within 24 h after tracheal intubation, and the changes in VCO2 and VO2 over 2 h were calculated as the slopes by linear regression analysis. Furthermore, temporal lactate changes were evaluated. The primary outcome was 28-day survival. Results Thirty-four patients with sepsis were enrolled, 26 of whom survived 76%. Significant differences in the slope of VCO2 (− 1.412 vs. − 0.446) (p = 0.012) and VO2 (− 2.098 vs. − 0.851) (p = 0.023) changes were observed between non-survivors and survivors. Of note, all eight non-survivors and 17 of the 26 survivors showed negative slopes of VCO2 and VO2 changes. For these patients, 17 survivors had a median lactate of − 2.4% changes per hour (%/h), whereas non-survivors had a median lactate of 2.6%/hr (p = 0.023). Conclusions The non-survivors in this study showed temporal decreases in both VCO2 and VO2 along with lactate elevation. Monitoring the temporal changes in VCO2 and VO2 along with blood lactate levels may be useful in predicting the prognosis of sepsis.

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Predictive Equation for Basal Metabolic Rate in Normal-Weight Chinese Adults

Wang,

Mao,

et al. 2023

Nutrients

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This study aimed to develop a predictive equation for basal metabolic rate (BMR) in normal-weight Chinese adults and provide a reference for establishing the national recommended dietary energy intake. A new equation for BMR was derived from a sample of 516 normal-weight Chinese adults (men = 253, women = 263), and this sample was collected from two previous studies. Furthermore, the accuracy of this new equation and eight other previous predictive equations was reviewed. The agreement and reliability were compared in terms of bias, accuracy, the intraclass correlation coefficient, and Bland–Altman plots between predictive equations. In addition, the newly developed equation was further verified using a small independent sample, which contained 41 healthy Chinese adults (men = 21, women = 20). The measured BMR (mBMR) of all participants, measured using indirect calorimetry, was 1346.2 ± 358.0 kcal/d. Thirty participants were excluded based on Cook’s distance criteria (Cook’s distance of ≥0.008). Previous equations developed by Henry, Schofield, Harris–Benedict (H-B), Yang, and Hong overestimated the BMR of healthy Chinese adults. The present equation displayed the smallest average bias (0.2 kcal/d) between the mBMR and predicted basal metabolic rate (pBMR). The limits of agreement of the present equation from Bland–Altman plots were −514.3 kcal/d and 513.9 kcal/d, which is the most narrow and balanced limit of agreement. Moreover, in the verification of the testing database, the pBMR of the new equation was not significantly different from the mBMR, and the accuracy was 75.6%. Compared with pre-existing equations, the present equation is more applicable to the prediction of BMR in healthy Chinese adults. However, further studies are required to verify the accuracy of this new equation.

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A novel prediction equation of resting energy expenditure for Japanese septic patients

Cited by 3 publications

References 36 publications

Methodological Aspects of Indirect Calorimetry in Patients with Sepsis—Possibilities and Limitations

Methodological Aspects of Indirect Calorimetry in Patients with Sepsis—Possibilities and Limitations

Changes in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis

Predictive Equation for Basal Metabolic Rate in Normal-Weight Chinese Adults

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