A novel precipitating-fluorochrome-based fluorescent probe for monitoring carbon monoxide during drug-induced liver injury

Fu, Gui-Qin; Xia, Yu-Sang; Jiang, Wenli; Wang, Wenxin; Tan, Zhi-Ke; Guo, Ke-Yue; Mao, Guojiang; Li, Chunyan

doi:10.1016/j.talanta.2022.123398

Cited by 12 publications

(3 citation statements)

References 49 publications

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“…Hydrogen sulfide (H 2 S) regulates gamma-aminobutyric acid B receptor receptors, pH balance, and calcium homeostasis and provides neuroprotection against oxidative stress [ 50 , 51 , 52 , 53 , 54 ]. Abnormal concentrations of CO are associated with inflammation, liver disease, diabetes, and cancer [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Types Of Neurochemicals and Associated Diseasesmentioning

confidence: 99%

Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals

Xu,

Zuo,

Chen

et al. 2024

Biosensors

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Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods. While lacking temporal resolution, techniques like HPLC and CE complement electrochemical sensing’s selectivity, particularly for structurally similar neurochemicals. This review covers essential neurochemicals and explores miniaturized electrochemical sensors for brain analysis, emphasizing microdialysis integration. It discusses the pros and cons of these techniques, forecasting electrochemical sensing’s future in neuroscience research. Overall, this comprehensive review outlines the evolution, strengths, and potential applications of electrochemical sensing in the study of neurochemicals, offering insights into future advancements in the field.

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Section: Types Of Neurochemicals and Associated Diseasesmentioning

confidence: 99%

Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals

Xu,

Zuo,

Chen

et al. 2024

Biosensors

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“…9b. 128 The probe has been ingeniously designed by incorporating the 1-ethyl-2-methylquinoline group that leads to the development of a long-emission precipitating fluorochrome (HPQ-MQ-OH), and the utilization of allyl formate as the CO identification component. Notably, HPQ-MQ-CO exhibits remarkable sensitivity and selectivity towards CO, and its reaction mechanism has been validated by mass spectrometry and high-performance liquid chromatography experiments.…”

Section: Fluorescent Probe Based On the Tsuji–trost Reaction Utilizin...mentioning

confidence: 99%

The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter

Liu

Qin

et al. 2023

Analyst

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“…In contrast, fluorescencebased assays are simple, rapid, and suitable for real-time on-site monitoring [13][14][15][16][17]. Since He's group [18] and Chang's group [19] reported a probe for CO detection in 2012, various fluorescent probes have been developed to detect CO [20][21][22][23][24][25][26]. Wang et al have developed a selective fluorescence cell imaging probe for CO.…”

Section: Introductionmentioning

confidence: 99%

A Turn-On Quinazolinone-Based Fluorescence Probe for Selective Detection of Carbon Monoxide

et al. 2023

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Carbon monoxide (CO) is a toxic, hazardous gas that has a colorless and odorless nature. On the other hand, CO possesses some physiological roles as a signaling molecule that regulates neurotransmitters in addition to its hazardous effects. Because of the dual nature of CO, there is a need to develop a sensitive, selective, and rapid method for its detection. Herein, we designed and synthesized a turn-on fluorescence probe, 2-(2′-nitrophenyl)-4(3H)-quinazolinone (NPQ), for the detection of CO. NPQ provided a turn-on fluorescence response to CO and the fluorescence intensity at 500 nm was increased with increasing the concentration of CO. This fluorescence enhancement could be attributed to the conversion of the nitro group of NPQ to an amino group by the reducing ability of CO. The fluorescence assay for CO using NPQ as a reagent was confirmed to have a good linear relationship in the range of 1.0 to 50 µM with an excellent correlation coefficient (r) of 0.997 and good sensitivity down to a limit of detection at 0.73 µM (20 ppb) defined as mean blank+3SD. Finally, we successfully applied NPQ to the preparation of a test paper that can detect CO generated from charcoal combustion.

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A novel precipitating-fluorochrome-based fluorescent probe for monitoring carbon monoxide during drug-induced liver injury

Cited by 12 publications

References 49 publications

Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals

Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals

The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter

A Turn-On Quinazolinone-Based Fluorescence Probe for Selective Detection of Carbon Monoxide

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