A novel potential therapy for vascular diseases: blood‐derived stem/progenitor cells specifically activated by dendritic cells

Porat, Yael; Assa-Kunik, Efrat; Belkin, Michael; Krakovsky, Michael; Lamensdorf, Itschak; Duvdevani, Revital; Sivak, Galit; Niven, Mark; Bulvik, Shlomo

doi:10.1002/dmrr.2543

Cited by 11 publications

(2 citation statements)

References 51 publications

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“…Stem cell treatments with BM-derived cells (BMDCs) show safety outcomes but also adverse events related to cell collection and mobilization. Porat et al postulated that alternatively activated dendritic cells (DCs) can promote the generation of EPC-enriched stem cells within a one-day culture [ 86 ].…”

Section: Resultsmentioning

confidence: 99%

Cell Therapy in Patients with Critical Limb Ischemia

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Massa

et al. 2015

Stem Cells International

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Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life.

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Section: Resultsmentioning

confidence: 99%

Cell Therapy in Patients with Critical Limb Ischemia

Compagna

Amato

Massa

et al. 2015

Stem Cells International

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“…In this issue of Diabetes Metabolism Research and Reviews, Porat et al report a method to treat vascular disease in diabetic patients with blood-derived stem or progenitor cells [15]. Using blood bank-donated samples from nondiabetic subjects, dendritic cells and stem/progenitor cells were enriched by antibody selection for cell surface markers.…”

mentioning

confidence: 99%