A novel porphyrin derivative and its metal complexes: Electrochemical, photoluminescence, thermal, DNA-binding and superoxide dismutase activity studies

Purtaş, Savaş; Köse, Muhammet; Tümer, Ferhan; Tümer, Mehmet; Gölcü, Ayşegül; Ceyhan, Gökhan

doi:10.1016/j.molstruc.2015.10.013

Cited by 15 publications

(3 citation statements)

References 37 publications

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“…Additionally, the DNA (fish sperm FSdsDNA) binding studies of the complex was performed by UV-vis spectroscopy (K b = 1.3 × 10 6 ). Competitive studies with ethidium bromide (K b = 1.23 ± 0.07 × 10 5 ) showed that the compounds interact efficiently with DNA through an intercalating way [ 213 ].…”

Section: Miscellanea Systemsmentioning

confidence: 99%

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

et al. 2020

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The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, in particular its lack of redox activity and its ability to support different coordination geometries and to promote fast ligands exchange. Analogously to other trace elements, the impairment of its homeostasis can lead to various diseases and in some cases can be also related to cancer development. However, in addition to its physiological role, zinc can have beneficial therapeutic and preventive effects on infectious diseases and, compared to other metal-based drugs, Zn(II) complexes generally exert lower toxicity and offer few side effects. Zinc derivatives have been proposed as antitumor agents and, among the great number of zinc coordination complexes which have been described so far, this review focuses on the design, synthesis and biological studies of zinc complexes comprising N-donor ligands and that have been reported within the last five years.

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Section: Miscellanea Systemsmentioning

confidence: 99%

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

et al. 2020

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“…•− , many disadvantages still exist [7], such as complex extract process, high cost, big molecular weight, easy deactivation, and not easily entering the cell membrane, which limited its application in medicine and other fields [8][9][10]. Therefore, the preparation of SOD mimic enzyme is becoming more and more popular [11,12].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Keratin-Glycine Metal Complexes and Their Scavenging Activity for Superoxide Anion Radicals

Wang

et al. 2018

International Journal of Polymer Science

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To address the problem of limited application of natural SOD, the development of SOD mimic enzymes is of great importance for bioantioxidation. Herein, we report on a new type of biopolymer antioxidant with excellent scavenging activity for O2•-, keratin-glycine metal complexes (FK-GlyM, M = Zn, Cu, Mn, Ni). They are prepared by feather keratin firstly combined with glycine and then metal ions. Using FT-IR, TG, CD, and SEM, the performance of the obtained complexes (FK-GlyM) for scavenging O2•- is analysed and investigated. Importantly, the scavenging activity of FK-GlyCu is excellent in all FK-GlyM, and FK-GlyCu60 has the most excellent anti-O2•- activity in all FK-GlyCux, of which EC50 and degree of simulation were, respectively, up to 4.5×10-3±0.0012 μmol/L and 911.1% compared with nature Cu, Zn-SOD. Finally, its mechanism was also discussed. In summary, this method about the simulation strategies will provide a novel idea for exploiting new-type biocompatible and highly reactive antioxidants.

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“…Fourier transform infrared (FT-IR) measurements for ZIF-8 and ZIF-8-Pp exhibit that the vibration of 421 and 1420 cm –1 can be attributed to the Zn–N bonds and C–N in imidazole rings respectively. Moreover, for Pp and ZIF-8-Pp, the vibrations at 800, 880, and 1594 cm –1 are assigned to the C–H, −CH 2 , and −C = N bonds of porphyrin molecules, respectively. The appearance of the vibrations from Pp and the imidazole ring in ZIF-8-Pp directly verify the immobilization of Pp onto ZIF-8 (Figure c).…”

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confidence: 99%

Overall Surfacial Antenna Immobilization Boosts Carrier Migration for Visible Light Superoxide Generation

Shi

et al. 2022

J. Phys. Chem. Lett.

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The artificial photosynthesis efficiency is restricted for the covering of introduced light-absorbing antennas, where they could generally be immobilized at specific surface sites of semiconductors. Here, we highlight the emerging π–π interaction strategies in realizing overall surfacial antenna immobilization onto semiconductor supports, during which large-scale built-in electric fields are established, strongly driving photocarrier migration to catalytic centers accompanied with enhanced light absorption. By taking porphyrin and ZIF-8 as a prototype, both theoretical calculation and experimental results show that the photocatalytic systems with overall surfacial antennas could absorb broader visible light and form abundant photocarrier transport pathways from porphyrin to ZIF-8, boosting the generation of superoxide and organic synthesis efficiency. This work develops a universal strategy for design of efficient artificial photosynthetic systems.

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A novel porphyrin derivative and its metal complexes: Electrochemical, photoluminescence, thermal, DNA-binding and superoxide dismutase activity studies

Cited by 15 publications

References 37 publications

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

Preparation of Keratin-Glycine Metal Complexes and Their Scavenging Activity for Superoxide Anion Radicals

Overall Surfacial Antenna Immobilization Boosts Carrier Migration for Visible Light Superoxide Generation

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