2021
DOI: 10.1093/femspd/ftab057
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A novel polypeptide vaccine and adjuvant formulation of EV71

Abstract: Hand foot and mouth disease (HFMD) is an infectious disease mainly caused by enterovirus 71 (EV 71). However, the effective treatment is limited currently. The aim of this study was to investigate the activity of the vaccine including the EV71 polypeptides mixed with a novel adjuvant containing CpG oligodeoxynucleotides (CpG ODNs). After collecting mouse sera, we determined the antibody concentration in serum by enzyme-linked immunosorbent assays (ELISA). Then CD19+ CD27+ B cells in the spleen were analyzed by… Show more

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“…This enhancement was attributed to various mechanisms such as Brownian motion (D. Li et al, 2020;Lozano-Steinmetz et al, 2022;Nabil et al, 2017), electron-phonon collision (Mateo et al, 2021), lattice vibration due to percolation effect (Yarmand et al, 2015) and enhanced surface area due to the clustering of Ag nanoparticles (Karthikeyan, Philip, and Raj, 2008;Philip and Shima, 2012;Gonçalves et al, 2021) on the GO surface. At 293 K, thermal conductivity enhancement of 8.03%, 11.04%, and 13.71% were observed, while at 333 K, the maximum enhancement of about 17.13%, 22.63%, and 30.12% were achieved at 0.03 M, 0.06 M, and 0.09 M Ag-GO, respectively, compared to the base fluid.…”
Section: Thermophysical Properties Of Hybrid Nanofluidmentioning
confidence: 99%
“…This enhancement was attributed to various mechanisms such as Brownian motion (D. Li et al, 2020;Lozano-Steinmetz et al, 2022;Nabil et al, 2017), electron-phonon collision (Mateo et al, 2021), lattice vibration due to percolation effect (Yarmand et al, 2015) and enhanced surface area due to the clustering of Ag nanoparticles (Karthikeyan, Philip, and Raj, 2008;Philip and Shima, 2012;Gonçalves et al, 2021) on the GO surface. At 293 K, thermal conductivity enhancement of 8.03%, 11.04%, and 13.71% were observed, while at 333 K, the maximum enhancement of about 17.13%, 22.63%, and 30.12% were achieved at 0.03 M, 0.06 M, and 0.09 M Ag-GO, respectively, compared to the base fluid.…”
Section: Thermophysical Properties Of Hybrid Nanofluidmentioning
confidence: 99%