A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice

Binding of the Biogenic Polyamines to Deoxyribonucleic Acids of Varying Base Composition: Base Specificity and the Associated Energetics of the Interaction

“…Studies have also demonstrated that a reduction of polyamine concentration usually has cytotoxic effects on cells through inhibition of growth or promotion of apoptosis in the cell. The effectiveness of polyamine analogs as antiproliferative agents against many tumor cell lines provides evidence for nucleic acid interaction [7]–[10]. Polyamines interaction with nucleic acids have also been shown to affect the stability of double and triple stranded DNA, protect DNA from oxidative stress, damaging agents, ionizing radiation, and endonuclease digestion etc [11]–[14].…”

Alkyl-Substituted Polyaminohydroxamic Acids: A Novel Class of Targeted Histone Deacetylase Inhibitors

“…This strategy was developed based on the observation that polyamine analogues can exert antitumor effects by virtue of their high affinity for DNA. [6][7][8][9] We postulated that these compounds could enter cells using the polyamine cellular transport system, 6,10 and could be selectively directed to DNA and associated histones, by virtue of the positively charged polyamine portion of the structure. In addition, it has been shown that histone deacetylases differ in primary sequence at specific residues in the rim region outside the lysine binding site.…”

Current Status of the Polyamine Research Field

“…Addition of terminal alkyl groups renders the analogs more resistant to metabolism and large numbers of analogs with both symmetrical terminal substituents and unsymmetrical terminal substituents have been made by the laboratories of Samejima, Bergeron, Woster, Frydman, and others (211, 217–223). Other internal modifications leading to conformational restriction of bis(ethyl) polyamines have provided particularly promising derivatives that are currently in clinical trials (224, 225). …”