A novel phenotype Of Zika virus‐related neurological disease: Sensory neuronopathy

Martinez, Alberto Rolim Muro; Costa, Marcela Câmara Machado; Novaes, Marco Antônio Caires; Lima, Humberto Castro; Nucci, Anamarli; França, Marcondes C.

doi:10.1002/mus.25958

Cited by 9 publications

(5 citation statements)

References 10 publications

(15 reference statements)

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“…ZIKV infection in the adult population has been linked to GBS, transverse myelitis, meningoencephalitis, peripheral neuropathy, and a host of ophthalmological complications (Acosta-Ampudia et al 2018). Based on these associations, a key question was whether the PNS was a direct target of infection or if the pathology was indirectly due to inflammatory responses, as was suggested by case reports of sensory neuropathy that developed weeks after the initial infection (Martinez et al 2017). In CNS and PNS myelinating cultures from Ifnar1 KO mice, all CNS cells were vulnerable to ZIKV infection, especially oligodendrocytes, but infection rates of PNS cells were much lower (Cumberworth et al 2017).…”

Section: Deficits In the Mature Nervous Systemmentioning

confidence: 99%

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System

Christian

Song

Ming

2019

Annu. Rev. Neurosci.

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In 2015, public awareness of Zika virus (ZIKV) rose in response to alarming statistics of infants with microcephaly being born to women who were infected with the virus during pregnancy, triggering global concern over these potentially devastating consequences. Although we have discovered a great deal about the genome and pathogenesis of this reemergent flavivirus since this recent outbreak, we still have much more to learn, including the nature of the virus-host interactions and mechanisms that determine its tropism and pathogenicity in the nervous system, which are in turn shaped by the continual evolution of the virus. Inevitably, we will find out more about the potential long-term effects of ZIKV exposure on the nervous system from ongoing longitudinal studies. Integrating clinical and epidemiological data with a wider range of animal and human cell culture models will be critical to understanding the pathogenetic mechanisms and developing more specific antiviral compounds and vaccines.

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Section: Deficits In the Mature Nervous Systemmentioning

confidence: 99%

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System

Christian

Song

Ming

2019

Annu. Rev. Neurosci.

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“…Congenital Zika Syndrome (SCZ) presents various sensory symptoms, including somatosensory ones (28,29). Despite numerous tests on hiPSC-derived neurons with ZIKV, there is yet no evidence that human sensory neurons can be infected.…”

Section: Effects Of Zika Virus and Saxitoxin On Human Sensory Neuronsmentioning

confidence: 99%

Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes

Souza,

Pedrosa,

Puig-Pijuan

et al. 2023

Preprint

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The Zika virus (ZIKV) outbreak in Brazil between 2015 and 2016 was associated with an increased prevalence of severe congenital malformations, including microcephaly. Notably, the distribution of microcephaly cases was not uniform across the country, with a disproportionately higher incidence recorded in the Northeast region (NE). Our previous work demonstrated that saxitoxin (STX), a toxin ubiquitously present in the drinking water reservoirs of the NE, exacerbated the damaging effects of ZIKV on the developing brain. In the present study, we hypothesized that STX's impact might vary among different neural cell types. Our experimental observations suggest that exposure to STX potentiates the neurotoxic effect of Zika Virus (ZIKV) on human neuronal cells. However, while ZIKV infection demonstrated severe impacts on astrocytes and neural stem cells (NSCs), the addition of STX did not exacerbate these effects. We observed that neurons subjected to STX exposure were more prone to apoptosis and displayed a higher number of ZIKV-infected cells. These findings suggest that STX exacerbates the harmful effects of ZIKV on neurons, thereby providing a plausible explanation for the heightened severity of ZIKV-induced congenital malformations observed in Brazil's NE. This study underscores the importance of understanding the interactive effects of environmental toxins and infectious pathogens on neural development, with potential implications for public health policies and interventions.

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“…Matinez et al 39 reported clinical and electrophysiological findings of a 42-year-old Brazilian woman with non–length-dependent and asymmetric selective sensory nerve involvement. The patient presented widespread reduction of sensory nerve action potential amplitudes, absent H reflexes bilaterally, but normal motor nerve conduction and needle EMG.…”

Section: Zika Virus–related Peripheral Nervous System Disordersmentioning

confidence: 99%

“…Matinez et al 39 reported clinical and electrophysiological findings of a 42-year-old Brazilian woman with non-lengthdependent and asymmetric selective sensory nerve involvement.…”

Section: Sensory Neuronopathymentioning

confidence: 99%

Clinical Neurophysiology of Zika Virus–Related Disorders of the Peripheral Nervous System in Adults

González-Salazar

Tartaglia

Dourado

et al. 2022

Journal of Clinical Neurophysiology

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Summary:During the 2013 to 2016 outbreak in the Pacific and Americas, Zika virus infection resulted not only in febrile and cutaneous manifestations but also in (severe) neurologic complications. These included both central and peripheral nervous system disorders. The most frequent was Guillain–Barré syndrome that typically developed 1 to 2 weeks after the acute infection. Later, other peripheral nervous system syndromes were recognized in association with the viral infection, broadening the spectrum of Zika virus–related peripheral nervous system syndromes. In the current article, the authors review all available clinical neurophysiology data on Guillain–Barré syndrome and other peripheral nervous system syndromes in an attempt to characterize the major patterns of involvement related to Zika virus. The authors also highlight the clinical usefulness of nerve conduction studies and needle EMG in the investigation of suspected Zika virus–related Guillain–Barré syndrome.

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A novel phenotype Of Zika virus‐related neurological disease: Sensory neuronopathy

Cited by 9 publications

References 10 publications

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System

Saxitoxin potentiates Zika virus-induced cell death in human neurons but not in neural progenitors and astrocytes

Clinical Neurophysiology of Zika Virus–Related Disorders of the Peripheral Nervous System in Adults

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