A novel phenotype of torpedo maculopathy on spectral-domain optical coherence tomography

Light, Jacob G.; Liu, T.Y. Alvin

doi:10.1016/j.ajoc.2020.100956

Cited by 7 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…proposed a type 4 phenotype with preservation of the ellipsoid zone, lack of subretinal fluid, and choroidal excavation. [ 11 ] Different subtypes can co-exist in the same lesion. [ 11 ] Our case is consistent with type 1 extrafoveal OCT morphology.…”

Section: Discussionmentioning

confidence: 99%

“…[ 11 ] Different subtypes can co-exist in the same lesion. [ 11 ] Our case is consistent with type 1 extrafoveal OCT morphology. This type is typically observed in younger patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors noted decrease signal in the deep capillary plexus in the area of torpedo lesion. [ 11 ] Grimaldi et al . supposed these abnormalities to be related to the patient's age.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Multimodal imaging of torpedo maculopathy with optical coherence tomography angiography

et al. 2023

View full text Add to dashboard Cite

A 24-year-old woman presented for routine clinical evaluation. Her best-corrected visual acuity was 20/20 and slit-lamp examination of the anterior segment was normal in both eyes. Fundus examination of the left eye revealed a hypopigmented lesion, one disc diameter temporal to the fovea, with a hyperpigmented tail extending temporally from the main lesion, consistent with a torpedo maculopathy. Fundus autofluorescence showed an hypoautofluorescence with hyperautofluorescent border. Swept-source optical coherence tomography (OCT) showed a normal inner retina and a degeneration of the outer retina without retinal cavitation. OCT angiography (OCT-A) of the choriocapillaris layer revealed reverse shadowing caused by the increased transmission from the atrophied outer retina and RPE within the torpedo lesion and attenuation of signal in the area of the temporal hyperpigmentation. The superficial capillary plexus was normal. This case includes a multimodal imaging with OCT-A of torpedo maculopathy in a Tunisian woman. Further reports are required to provide a better understanding of this rare condition.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[ 11 ] Different subtypes can co-exist in the same lesion. [ 11 ] Our case is consistent with type 1 extrafoveal OCT morphology. This type is typically observed in younger patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multimodal imaging of torpedo maculopathy with optical coherence tomography angiography

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Although the sample size for this descriptive study was limited by the low prevalence of TM, we were able to image both variants, type I and II, in detail. Clinically, TM can present with varying appearance and new possible lesion subtypes ( 32 ) may still be discovered such as those presenting with vitelliform material ( 33 ). Near infrared autofluorescence imaging using adaptive optics is an exciting new field and more quantitative results are possible in future studies.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Imaging of Torpedo Maculopathy With Fluorescence Adaptive Optics Imaging of Individual Retinal Pigmented Epithelial Cells

et al. 2021

View full text Add to dashboard Cite

Torpedo maculopathy (TM) is a rare congenital defect of the retinal pigment epithelium (RPE). The RPE is often evaluated clinically using fundus autofluorescence (AF), a technique that visualizes RPE structure at the tissue level from the intrinsic AF of RPE fluorophores. TM lesions typically emit little or no AF, but this macroscopic assessment is unable to resolve the RPE cells, leaving the organization of the RPE cell mosaic in TM unknown. We used fluorescence adaptive optics scanning laser ophthalmoscopy (AOSLO) to show here for the first time the microscopic cellular-level structural alterations to the RPE cell mosaic in TM that underlie the tissue-level changes seen in conventional clinical imaging. We evaluated two patients with TM using conventional clinical imaging techniques and adaptive optics (AO) infrared autofluorescence (IRAF) in AOSLO. Confocal AOSLO revealed relatively normal cones outside the TM lesion but altered cone appearance within it and along its margins in both patients. We quantified cone topography and RPE cell morphometry from the fovea to the margin of the lesion in case 1 and found cone density to be within the normal range across the locations imaged. However, RPE morphometric analysis revealed disrupted RPE cells outside the margin of the lesion; the mean RPE cell area was greater than two standard deviations above the normative range up to approximately 1.5 mm from the lesion margin. Similar morphometric changes were seen to individual RPE cells in case 2. Multi-modal imaging with AOSLO reveals that RPE cells are abnormal in TM well beyond the margins of the characteristic TM lesion boundary defined with conventional clinical imaging. Since the TM fovea appears to be fully formed, with normal cone packing, it is possible that the congenital RPE defect in TM occurs relatively late in retinal development. This work demonstrates how cellular level imaging of the RPE can provide new insight into RPE pathologies, particularly for rare conditions such as TM.

show abstract

“…2 It manifests as variable defects in the outer layers of the retina and four types have been described. [3][4][5] In 1992, Roseman and Gass 6 described the features of a "hypopigmented nevus of the retinal pigment epithelium," later termed torpedo maculopathy by Daily MJ. 7 This condition is characterized by an asymptomatic oval torpedo-shaped defect in the RPE, specifically located in the temporal macular region, with a pointed tip directed toward the foveola.…”

Section: Introductionmentioning

confidence: 99%

Association of torpedo maculopathy and keratoconus in a young patient: A multimodal imaging study

Cozzupoli,

Fasciani,

Fedeli

et al. 2023

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To report and document a case of torpedo maculopathy found in a patient affected by keratoconus. Case report: An healthy 16-year-old male patient, affected by keratoconus in both eyes, was referred to the cornea service of our hospital for a follow-up visit. During the dilated fundus examination of the left eye, an oval, well-demarcated, hypopigmented lesion was observed in the juxtafoveal temporal region, pointing towards the center of the macula. Multimodal imaging of the lesion was performed, and the diagnosis of Torpedo Maculopathy was established based on the clinical picture. Conclusion This is the first case of torpedo maculopathy described in a patient affected by keratoconus. This association may be merely fortuitous or the result of developmental abnormalities affecting both corneal and retinal structures.

show abstract

A novel phenotype of torpedo maculopathy on spectral-domain optical coherence tomography

Cited by 7 publications

References 13 publications

Multimodal imaging of torpedo maculopathy with optical coherence tomography angiography

Multimodal imaging of torpedo maculopathy with optical coherence tomography angiography

Multimodal Imaging of Torpedo Maculopathy With Fluorescence Adaptive Optics Imaging of Individual Retinal Pigmented Epithelial Cells

Association of torpedo maculopathy and keratoconus in a young patient: A multimodal imaging study

Contact Info

Product

Resources

About