A novel phenotype for Laron dwarfism in miniature Bos indicus cattle suggests that the expression of growth hormone receptor 1A in liver is required for normal growth☆

Liu, J; Boyd, C. K.; Kobayashi, Yasuhiro; Chase, C. C.; Hammond, A. C.; Olson, T. A.; Elsasser, Theodore H.; Lucy, M.C.

doi:10.1016/s0739-7240(99)00051-x

Cited by 25 publications

(7 citation statements)

References 32 publications

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“…It is reported that a novel phenotype for Laron dwarfism in Bos indicus cattle was associated with underexpression of GHR 1A mRNA, but not other GHR mRNA variants in the liver [14]. The study of Zeng et al [27] showed that GRH 1 and 2 were correlated with each other in adult tissues of blunt snout bream and megalobrama amblycephala.…”

Section: Discussionmentioning

confidence: 98%

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

Chen¹,

Cui²,

Yu³

2018

Folia Morphol

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Section: Discussionmentioning

confidence: 98%

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

Chen¹,

Cui²,

Yu³

2018

Folia Morphol

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“…One of the famous short height diseases is Laron's syndrome dwarfism, which is caused by a defect in the GH receptor or in post-receptor mechanisms [2,9]. GR cattle seem to have similar characteristics to this syndrome, but there are two big differences.…”

Section: Discussionmentioning

confidence: 99%

Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Ishida

Yonezawa

Eirai³

et al. 2013

J. Vet. Med. Sci.

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ABSTRACT. Japanese Black cattle occasionally demonstrate growth retardation despite sufficient nutrient intake. To clarify hormonal and transcriptional characteristics, we investigated differences in blood components, including hormones, and differences in exhaustive gene expressions in the liver and peripheral lymphocytes of six cattle with growth retardation (GR cattle) and eight control cattle of the same age and pedigree with normal growth. Hematocrit values and concentrations of hemoglobin, serum albumin, total cholesterol, insulin-like growth factor 1 (IGF-1), thyroxine and insulin in GR cattle were significantly lower than those in controls. GR cattle also excreted higher levels of GH. We used three GR and three control cattle for a microarray analysis in the liver and found that 279 gene expressions were significantly different. However, gene expressions related to the GH-IGF-1 axis, such as the GH receptor and IGF-1, were not significantly different from those of controls. Immune-related gene expressions were significantly lower. To clarify these gene expression levels, peripheral lymphocytes were used for real-time RT-PCR. The expression rates of genes that were significantly lower in the liver, such as chemokine ligand 8, interferon gamma receptor 1 and immunoglobulin light chain VJ region were also significantly lower in three GR cattle than those in the three control cattle. These results suggest that the cause of growth retardation in the present study was due to other factors, not abnormal gene expressions of factors related to the GH-IGF-1 axis in the liver, and that GR cattle were susceptible to infectious disease.

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“…However, such remarkable symptoms were not observed in ateliotic cattle in the present study. The GH-IGF-1 axis of the MHO cattle also suggests the possibility of either a low expression or defect of GH receptors similar to Laron syndrome type dwarfism in cattle, an abnormality in post-receptor mechanisms similar to human Pigmy type dwarfism [3,10,12], or molecular GH defects. These hereditary diseases, however, have yet to be detected in Japanese black cattle, and we have no data indicating that the abnormality in the GH-IGF-1 axis in the ateliotic cattle was hereditary.…”

Section: Discussionmentioning

confidence: 99%

Endocrine Patterns in Two Strains of Japanese Black Cattle with Growth Retardation

Takasu

Hagiwara

Ohba

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. Endocrine patterns were compared in 2 strains of Japanese black cattle with growth retardation; MHO-and HSK-paternal strains (MHO and HSK cattle, respectively). MHO cattle (n=8) displayed lower serum concentrations of insulin-like growth factor-1 (IGF-1), triiodothyronine (T3), thyroxine (T4), and cortisol (31.1 ± 20.7 ng/ml, 73.9 ± 51.9 ng/dl, and 2.9 ± 2.9 µg/dl, 1.3 ± 0.7 µg/dl, respectively) than those in both HSK cattle (n=5) (64.9 ± 47.6 ng/ml, 97.8 ± 40.7 ng/dl, 4.1 ± 2.1 µg/dl and 1.8 ± 1.1 µg/dl, respectively), and the controls (n=6) (314.7 ± 197.2 ng/ml, 140.2 ± 21.3 ng/dl, 5.8 ± 1.7 µg/dl, and 3.0 ± 1.4 µg/dl, respectively). The area under the concentration curve of growth hormone (GH-AUC 0-600 min) in MHO cattle (22210 ± 18951 ng•min/ml) tended to be greater than those in HSK (7887 ± 6340 ng•min/ml) and the controls (2811 ± 1275 ng•min/ml). MHO cattle showed a high GH-AUC 0-600 min in contrast to a low serum IGF-1 concentration, as well as lower serum T3, T4, and cortisol concentrations. HSK cattle exhibited the same secretory patterns, but much more moderately. Growth retardation in Japanese black cattle exhibits some variations based on pedigree. KEY WORDS: endocrine pattern, growth retardation, Japanese black cattle.

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A novel phenotype for Laron dwarfism in miniature Bos indicus cattle suggests that the expression of growth hormone receptor 1A in liver is required for normal growth☆

Cited by 25 publications

References 32 publications

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Endocrine Patterns in Two Strains of Japanese Black Cattle with Growth Retardation

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