A novel pH-sensitive membrane from chitosan — TEOS IPN; preparation and its drug permeation characteristics

Physical Characteristics of Chitosan Based Film Modified With Silica and Polyethylene Glycol

“…These hydrophilic groups are considered to play an important role in preferential water sorption and diffusion through the chitosan film. It is especially attractive due to its film forming characteristic and finds multiple uses in application of coating, drug delivery, nutrients, controlled release of food ingredients, separation techniques, optical material, and so forth [1][2].…”

“…On the other hand, formation of organic-inorganic composite film provides another approach to improve the physicochemical properties of chitosan and other biomaterials. Introduction of silica into the chitosan film increases its oxygen permeability, biocompatibility, and biodegradability [1][2][3][4][5][6][7][8].…”

“…Chitosan-silica composite for pH-sensitive film [2] and biodegradable/biocompatible materials prepared from tetraethoxysilane (TEOS) [2], tetraethoxysilane/vinyl triethoxysilane (TEOS/VTES) [1], 3-aminopropyltriethoxy silane [7], α-(glycidyloxypropyl)trimethoxysilane (GPTMS) [1], polydimethylsiloxane [8] have been reported.…”

“…In spite the formation of hydrogen bonding between the silanol groups and the chitosan film that is expected to promote the compatibility between the organic and the inorganic phases, the lack of covalent bonding in the silica and polymer domains certainly to limit their compatibility [2]. The thermo stability and mechanical performances of the composite films are higher than that of chitosan film and increased with increasing the amount of silica added.…”

“…The thermo stability and mechanical performances of the composite films are higher than that of chitosan film and increased with increasing the amount of silica added. However, the mechanical performance deteriorates with the excessive silica [1][2][3][5][6][7][8]. Addition of food-grade plasticizers (polyethylene glycol, PEG) to film-forming alleviates this problem.…”