A novel peptide derived fromHaematococcus pluvialisresidue exhibits anti-aging activity inCaenorhabditis elegans viathe insulin/IGF-1 signaling pathway

He, Wanshi; Xie, Junting; Xia, Zenghui; Chen, Xiaoyan; Xiao, Jie; Cao, Yong; Liu, Xiaojuan

doi:10.1039/d3fo00383c

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…Enzymatic hydrolysates of H. pluvialis residue protein was also reported to play antioxidant properties in vitro 26) . A recent study reported peptides derived from H. pluvialis residue displayed anti-aging activity in Caenorhabditis elegans 27) .…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin, Haematococcus pluvialis and Haematococcus pluvialis Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Zhang,

Gao,

Zhu

et al. 2024

J. Oleo Sci.

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tive diseases, and liver diseases 1) . Liver is an important organ that is essential for maintaining whole-body metabolic homeostasis. The process of aging leads to gradual damage to the structure and function of liver 2) . One of the most accepted mechanisms underlying aging is oxidative Abstract: Astaxanthin is a keto-based carotenoid mainly obtained from marine organisms, like Haematococcus pluvialis (H. pluvialis). Previous studies indicated the protective effects of Astaxanthin and H. pluvialis on aging related oxidative injury in liver, while the potential mechanisms are largely unknown. In addition, H. pluvialis residue is a by-product after astaxanthin extraction, which is rarely studied and utilized. The present study aimed to compare the effects of astaxanthin, H. pluvialis and H. pluvialis residue on the oxidant injury of liver in D-galactose-induced aging mice and explore the potential mechanisms through gut-liver axis. The results showed that all the three supplements prevented D-galactose-induced tissue injury, oxidative stress and chronic inflammation in liver and improved liver function. Gut microbiota analysis indicated that astaxanthin notably increased fecal levels of Bacteroidetes, unclassified_f__ Lachnospiraceae, norank_f__Lachnospiraceae, norank_f__norank_o__Clostridia_UCG-014, Prevotellaceae_ UCG-001, unclassified_f__Prevotellaceae in D-galactose-fed mice (p < 0.05). Compared to aging mice, H. pluvialis group had higher fecal levels of norank_f__Lachnospiraceae and Lachnospiraceae_UCG-006 (p < 0.05). H. pluvialis residue group displayed higher relative levels of Bacteroidetes, Streptococcus, and Rikenellaceae_RC9_gut_group (p < 0.05). Moreover, the production of fecal microbial metabolites, like SCFAs and LPS was also differently restored by the three supplements. Overall, our results suggest astaxanthin, H. pluvialis and H. pluvialis residue could prevent aging related hepatic injury through gutliver axis and provide evidence for exploiting of H. pluvialis residue as a functional ingredient for the treatment of liver diseases. Future studies are needed to further clarify the effect and mechanism of dominant components of H. pluvialis residue on liver injury, which is expected to provide a reference for the high-value utilization of H. pluvialis resources.

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Section: Discussionmentioning

confidence: 99%

Astaxanthin, Haematococcus pluvialis and Haematococcus pluvialis Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Zhang,

Gao,

Zhu

et al. 2024

J. Oleo Sci.

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Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives

Yao,

Zhang,

Zhang

2024

Food Chemistry

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Unlocking the potential of chicken liver byproducts: Identification of antioxidant peptides through in silico approaches and anti-aging effects of a selected peptide in Caenorhabditis elegans

Chen,

Nie,

Huang

et al. 2024

International Journal of Biological Macromolecules

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A novel peptide derived fromHaematococcus pluvialisresidue exhibits anti-aging activity inCaenorhabditis elegans viathe insulin/IGF-1 signaling pathway

Abstract: To explore the value of Haematococcus pluvialis (H. pluvialis) residues remaining after astaxanthin extraction and being discarded uneconomically, our previous study discovered the novel peptide (HPp) as a potential bioactive...

Cited by 4 publications

References 65 publications

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives

Unlocking the potential of chicken liver byproducts: Identification of antioxidant peptides through in silico approaches and anti-aging effects of a selected peptide in Caenorhabditis elegans

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