A novel particle engineering method for the production of inhalable cromolyn sodium powders by a combination of spray drier and nebulizer

Hamedani, Sana; Yaqoubi, Shadi; Safdari, Rezvan; Hamishehkar, Hamed; Nokhodchi, Ali

doi:10.1016/j.jddst.2022.103958

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Those percentages, besides the amount of VAN deposited in stage 1 (9%), correspond to the quantity of drug that will not reach the deep lung. The presence of a high amount of drug from stage 2 onwards is considered desirable for lung deposition [ 46 ]; since this stage has a cut-off diameter of 4.46 µm at the flow rate of 65 L/min, almost half of particles of HA-VAN 25 are in these stages. The higher values of VAN in stage 2 and 3 in comparison with the following is consistent with the MMAD value obtained.…”

Section: Resultsmentioning

confidence: 99%

Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Magi,

de Lafuente,

Quarta

et al. 2024

Pharmaceutics

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Polyelectrolyte–drug complexes are interesting alternatives to improve unfavorable drug properties. Vancomycin (VAN) is an antimicrobial used in the treatment of methicillin-resistant Staphylococcus aureus pulmonary infections in patients with cystic fibrosis. It is generally administered intravenously with a high incidence of adverse side effects, which could be reduced by intrapulmonary administration. Currently, there are no commercially available inhalable formulations containing VAN. Thus, the present work focuses on the preparation and characterization of an ionic complex between hyaluronic acid (HA) and VAN with potential use in inhalable formulations. A particulate–solid HA-VAN25 complex was obtained by spray drying from an aqueous dispersion. FTIR spectroscopy and thermal analysis confirmed the ionic interaction between HA and VAN, while an amorphous diffraction pattern was observed by X-ray. The powder density, geometric size and morphology showed the suitable aerosolization and aerodynamic performance of the powder, indicating its capability of reaching the deep lung. An in vitro extended-release profile of VAN from the complex was obtained, exceeding 24 h. Microbiological assays against methicillin-resistant and -sensitive reference strains of Staphylococcus aureus showed that VAN preserves its antibacterial efficacy. In conclusion, HA-VAN25 exhibited interesting properties for the development of inhalable formulations with potential efficacy and safety advantages over conventional treatment.

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Section: Resultsmentioning

confidence: 99%

Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Magi,

de Lafuente,

Quarta

et al. 2024

Pharmaceutics

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“…Furthermore, to modulate the chemical-physical properties of the particles, ammonium bicarbonate (AB) was added to the liquid feed immediately before being processed, at AB concen-trations of 10 wt% (PVA : LEU_AB10) and 20 wt% (PVA : LEU_AB20) with respect to the total PVA : LEU mixture. AB is a pore-forming agent widely used in the SD process to obtain porous particles 55,56 as it decomposes above 50 °C giving rise to the gas responsible for the formation of pores/ bubbles, which modulate the chemical-physical characteristics as well as the aerodynamic properties of obtained particles. 37,57 In Table 2, the composition of the liquid feeds to obtain each microparticle sample is reported.…”

Section: Paper Biomaterials Sciencementioning

confidence: 99%

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Craparo,

Cabibbo,

Scialabba

et al. 2024

Biomater. Sci.

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“…An in vitro study on the NGI apparatus revealed that the particles with ammonium bicarbonate showed depositions in stages 3 and 4. Despite excellent performance, limitations include unsuitability for temperature-sensitive ingredients, lower yield, and the development of a crystal structure, which further reduces the efficacy of the formulation [ 93 ].…”

Section: Approaches For Particle Engineeringmentioning

confidence: 99%

Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches

Negi,

Nimbkar,

Moses

2023

Pharmaceutics

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Respirable particles are integral to effective inhalable therapeutic ingredient delivery, demanding precise engineering for optimal lung deposition and therapeutic efficacy. This review describes different physicochemical properties and their role in determining the aerodynamic performance and therapeutic efficacy of dry powder formulations. Furthermore, advances in top-down and bottom-up techniques in particle preparation, highlighting their roles in tailoring particle properties and optimizing therapeutic outcomes, are also presented. Practices adopted for particle engineering during the past 100 years indicate a significant transition in research and commercial interest in the strategies used, with several innovative concepts coming into play in the past decade. Accordingly, this article highlights futuristic particle engineering approaches such as electrospraying, inkjet printing, thin film freeze drying, and supercritical processes, including their prospects and associated challenges. With such technologies, it is possible to reshape inhaled therapeutic ingredient delivery, optimizing therapeutic benefits and improving the quality of life for patients with respiratory diseases and beyond.

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A novel particle engineering method for the production of inhalable cromolyn sodium powders by a combination of spray drier and nebulizer

Cited by 4 publications

References 25 publications

Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Novel Dry Hyaluronic Acid–Vancomycin Complex Powder for Inhalation, Useful in Pulmonary Infections Associated with Cystic Fibrosis

Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles

Engineering Inhalable Therapeutic Particles: Conventional and Emerging Approaches

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