A novel onco-miR-365 induces cutaneous squamous cell carcinoma

Zhou, Meijuan; Li, Weilin; Ma, Shudong; Cao, Hong; Peng, Xuebiao; Guo, Ling; Zhou, Xinhua; Li, Zheng; Guo, Linlang; Wan, Miaojian; Shi, Weimin; He, Yun; Lü, Chao; Jiang, Lihong; Ou, Chengshan; Guo, Yuanxia; Ding, Zhenhua

doi:10.1093/carcin/bgt097

Cited by 64 publications

(77 citation statements)

References 33 publications

(32 reference statements)

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“…MiR-365 expression has been so far associated to cancer development and its progression (Zhou et al, 2013). The finding that miR-365 may be related to transport-stress confirms what has been recently reported by Ahanda et al (2014), who demonstrated that miR-365 family members are present in plasma and red blood, but not white blood cells, and their expression is modulated by food deprivation stress.…”

Section: Discussionsupporting

confidence: 84%

Circulating extracellular miR-22, miR-155, and miR-365 as candidate biomarkers to assess transport-related stress in turkeys

Lecchi

Marques

Redegalli

et al. 2016

Animal

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MicroRNA (miRNA) have been identified in circulating blood and might have the potential to be used as biomarkers for several pathophysiological conditions. To identify miRNA that are altered following stress events, turkeys (Meleagris gallopavo) were subjected to 2 h of road transportation. The expression levels of five circulating miRNA, namely miR-22, miR-155-5p, miR-181a-3p, miR-204 and miR-365-3p, were detected and assessed by quantitative polymerase chain reaction using TaqMan ® probes, as potential biomarkers of stress. The areas under the receiver operating characteristic curves were then used to evaluate the diagnostic performance of miRNA. A panel of three stress-responsive miRNA, miR-22, miR-155 and miR-365 were identified; their expression levels were significantly higher after road transportation and the area under the curve (AUC) were 0.763, 0.71 and 0.704, respectively. Combining the three miRNA a specificity similar to the one found for the three miRNA separately was found. The AUC of the weighted average of the three miRNA was 0.763. This preliminary study suggests that the expression levels of circulating miR-22, miR-155 and miR-365 are increased during transport-related stress and that they may have diagnostic value to discriminate between stressed-and unstressed animals.

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Section: Discussionsupporting

confidence: 84%

Circulating extracellular miR-22, miR-155, and miR-365 as candidate biomarkers to assess transport-related stress in turkeys

Lecchi

Marques

Redegalli

et al. 2016

Animal

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“…We previously demonstrated that miR-365 has a procarcinogenic role in CSCC by targeting NFIB (Zhou et al, 2013(Zhou et al, , 2014. Thus, CDK6, as a downstream factor, is also affected and , and CDK4 were detected in the CSCC cell lines Tca8113, HSC-1, and A431 and in normal HaCaT cells by qRT-PCR and western blotting.…”

Section: The Mrna and Proteins Levels Of Cdk6 And Cdk4 Are Highly Uprmentioning

confidence: 97%

“…We previously identified microRNA-365 (miR-365) as an oncomiR that is highly expressed in CSCC cells and clinical tumors (Zhou et al, 2013). Further study of this microRNA led to the identification of a downstream target of miR-365, nuclear factor I/B (NFIB) (Zhou et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

microRNA-365-targeted nuclear factor I/B transcriptionally represses cyclin-dependent kinase 6 and 4 to inhibit the progression of cutaneous squamous cell carcinoma

Zhou

Wang

et al. 2015

The International Journal of Biochemistry & Cell Biology

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“…A previous study confirmed that miR-365 was downregulated in colon cancer tissues, was involved in tumor progression and poor survival, and regulated cancer cell behavior by targeting cyclin D1 and Bcl-2 (16). miR-365 was also overexpressed both in cells and cutaneous squamous cell carcinoma tissues, suggesting that miR-365 may act as an oncogene both in vitro and in vivo (17). Moreover, recent studies indicated that miR-365 was upregulated in breast cancer (18).…”

Section: Introductionmentioning

confidence: 73%

miR-365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer

Liu

Zang

et al. 2015

International Journal of Oncology

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Abstract. MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, including breast cancer. We evaluated miR-365 expression in breast cancer tissues, and investigated its effects on cell growth, cell cycle, cell invasion, and expression of its target gene ADAMTS-1. miR-365 expression levels were analyzed in breast cancer tissues and adjacent normal tissues using qRT-PCR. CCK-8, cell cycle, and invasion assays were used to explore the role of miR-365 expression in breast cancer cells. We conducted luciferase reporter and western blot assays to test whether ADAMTS-1 is a direct target of miR-365. We found that miR-365 expression levels were significantly higher in breast cancer tissues compared with adjacent non-tumor tissues (P<0.05). These relatively high expression levels were significantly associated with advanced clinical stages (P<0.05). In breast cancer cell lines, transfection with miR-365 inhibitor suppressed proliferation and invasion, and resulted in cell cycle arrest. Subsequent experiments indicated that miR-365 bound the 3'-UTR of ADAMTS-1 and downregulated its expression. Our findings indicated that the inhibition of miR-365 reduced cell proliferation and cell invasion. Additionally, miR-365 may function as a novel oncogene in breast cancer through targeting ADAMTS-1. These findings provide insight into the mechanism of breast cancer pathogenesis.

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A novel onco-miR-365 induces cutaneous squamous cell carcinoma

Cited by 64 publications

References 33 publications

Circulating extracellular miR-22, miR-155, and miR-365 as candidate biomarkers to assess transport-related stress in turkeys

Circulating extracellular miR-22, miR-155, and miR-365 as candidate biomarkers to assess transport-related stress in turkeys

microRNA-365-targeted nuclear factor I/B transcriptionally represses cyclin-dependent kinase 6 and 4 to inhibit the progression of cutaneous squamous cell carcinoma

miR-365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer

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