A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study

Gangaram-Panday, Norani H.; Nijenhuis, Louwrina H. te; Fine, Ilya; Weteringen, Willem van

doi:10.1038/s41598-022-10911-8

Cited by 3 publications

(3 citation statements)

References 58 publications

(45 reference statements)

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“…Since erythromelalgia presents with pain, warmth, and erythema in distal extremities, it is natural to consider possible roles of small-vessel vasculopathy in its pathogenesis. Non-invasive techniques for assessing micro-circulation [ 27 ] and large-vessel vasculopathy [ 28 ] are under evaluation for other pediatric diseases and could be considered in future prospective studies.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series

Sun,

Ocay,

Halpin

et al. 2023

Children

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Erythromelalgia is a descriptive term for severe burning pain and erythema in the distal extremities relieved by cold and exacerbated by heat. Pediatric case series to date are relatively small. We extracted and analyzed medical record data for 42 pediatric patients to describe clinical characteristics, associated conditions, and responses to treatments. Informed consent was obtained according to an IRB-approved protocol that included gene discovery. Three patients had confirmed Nav1.7 sodium channelopathies, with six additional patients under investigation with novel gene candidates. There was a female predominance (2.5:1), and the median onset age was 12 years (IQR = 3–14). Patients saw a median of three specialists (IQR = 2–3) for a diagnosis. The majority (90%) reported bilateral symptoms. Cooling methods usually provided partial relief, while heat and exercise exacerbated pain. No medication appeared to be consistently effective; commonly prescribed medications included sodium channel blockers (n = 37), topical analgesics (n = 26), gabapentin (n = 22), and aspirin (n = 15). Based on the currently published literature, we believe this cohort is the largest pediatric study of erythromelalgia to date. Many findings are consistent with those of previously published case series. Work is in progress to establish a prospective cohort and multi-center registry.

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Section: Discussionmentioning

confidence: 99%

Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series

Sun,

Ocay,

Halpin

et al. 2023

Children

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“…Laser Doppler [47], dynamic light scattering [48 ▪ ] and thermographic imaging have also been used to describe skin perfusion changes [49 ▪ ].…”

Section: Microcirculationmentioning

confidence: 99%

Resuscitating the macro- vs. microcirculation in septic shock

González,

Urbano,

López-Herce

2024

Current Opinion in Pediatrics

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Purpose of review This review summarizes current literature about the relationships between macro and microcirculation and their practical clinical implications in children with septic shock. Recent findings Current evidence from experimental and clinical observational studies in children and adults with septic shock reveals that the response to treatment and resuscitation is widely variable. Furthermore, there is a loss of hemodynamic coherence, as resuscitation-induced improvement in macrocirculation (systemic hemodynamic parameters) does not necessarily result in a parallel improvement in the microcirculation. Therefore, patient-tailored monitoring is essential in order to adjust treatment requirements during resuscitation in septic shock. Optimal monitoring must integrate macrocirculation (heart rate, blood pressure, cardiac output, and ultrasound images), microcirculation (videomicroscopy parameters and capillary refill time) and cellular metabolism (lactic acid, central venous blood oxygen saturation, and difference of central venous to arterial carbon dioxide partial pressure). Summary There is a dire need for high-quality studies to assess the relationships between macrocirculation, microcirculation and tissue metabolism in children with septic shock. The development of reliable and readily available microcirculation and tissue perfusion biomarkers (other than lactic acid) is also necessary to improve monitoring and treatment adjustment in such patients.

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“…A method of assessing tissue perfusion is the measurement of blood flow in the microcirculation. Despite the vast interest in measurement of the microcirculation, monitoring techniques are still mostly experimental and difficult to implement in clinical practice [ 16 ].…”

mentioning

confidence: 99%

Fluid Therapy from Friend to Foe

Fodor

2023

The Journal of Critical Care Medicine

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A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study

Cited by 3 publications

References 58 publications

Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series

Clinical Characterization of Pediatric Erythromelalgia: A Single-Center Case Series

Resuscitating the macro- vs. microcirculation in septic shock

Fluid Therapy from Friend to Foe

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