A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport

Fidan-Yardimci, Melike; Akay, Seref; Sharifi, Fatemeh; Sevimli-Gur, Canan; Öngen, Gaye; Yeşil-Çeliktaş, Özlem

doi:10.1016/j.foodchem.2019.04.086

Cited by 51 publications

(19 citation statements)

References 39 publications

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“…Capsules were prepared with polycaprolactone as a coating material. According to in vitro data, just about 90% of anthocyanins were released within 10 h making this new niosomal technique suitable for anthocyanin delivery [ 243 ].…”

Section: Bioavailability Of Encapsulated Phenolic Compoundsmentioning

confidence: 99%

Role of the Encapsulation in Bioavailability of Phenolic Compounds

et al. 2020

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Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of phenolic compounds significantly depend on the structure and form in which they are introduced into the organism, e.g., through a complex food matrix or as purified isolates. Furthermore, phenolic compounds interact with other macromolecules (proteins, lipids, dietary fibers, polysaccharides) in food or during digestion, which significantly influences their bioaccessibility in the organism, but due to the complexity of the mechanisms through which phenolic compounds act in the organism this area has still not been examined sufficiently. Simulated gastrointestinal digestion is one of the commonly used in vitro test for the assessment of phenolic compounds bioaccessibility. Encapsulation is a method that can positively affect bioaccessibility and bioavailability as it ensures the coating of the active component and its targeted delivery to a specific part of the digestive tract and controlled release. This comprehensive review aims to present the role of encapsulation in bioavailability of phenolic compounds as well as recent advances in coating materials used in encapsulation processes. The review is based on 258 recent literature references.

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Section: Bioavailability Of Encapsulated Phenolic Compoundsmentioning

confidence: 99%

Role of the Encapsulation in Bioavailability of Phenolic Compounds

et al. 2020

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“…A solution to overcome these drawbacks could be the encapsulation of SE extract in various carriers. For the encapsulation of bioactive compounds or extracts, several carriers have been reported: (i) natural or synthetic polymers [11,12]; (ii) micro/nanofibers [13,14]; (iii) lipids including micro/nanoemulsions, lipid vesicles and solid lipid nanoparticles [15][16][17][18]; (iv) cyclodextrins [19,20]; and (v) other types, e.g., niosomes, inorganic nanoparticles and nanocrystals [21,22].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

et al. 2019

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The paper deals with the preparation and characterisation of hydroalcoholic polyphenolic extract from Sambucus ebulus (SE) leaves that was further loaded into three-types of lipid vesicles: liposomes, transfersomes, and ethosomes, to improve its bioavailability and achieve an optimum pharmacological effect. For Sambucus ebulus L.-loaded lipid vesicles, the entrapment efficiency, particle size, polydispersity index and stability were determined. All prepared lipid vesicles showed a good entrapment efficiency, in the range of 75–85%, nanometric size, low polydispersity indexes, and good stability over three months at 4 °C. The in vitro polyphenols released from lipid vehicles demonstrated slower kinetics when compared to the free extract dissolution in phosphate buffer solution at pH 7.4. Either free SE extract or SE extract loaded into lipid vesicles demonstrated a cytoprotective effect, even at low concentration, 5 ug/mL, against hydrogen peroxide-induced toxicity on L-929 mouse fibroblasts’ cell lines. However, the cytoprotective effect depended on the time of the cells pre-treatment with SE extract before exposure to a hydrogen peroxide solution of 50 mM concentration, requiring at least 12 h of pre-treatment with polyphenols with radical scavenging capacity.

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“…In addition, niosomes, self-assembled vesicles, are formed by hydration of non-ionic surfactant, cholesterol, or other amphiphilic molecules and are able to transport both hydrophilic and hydrophobic molecules. Their chemical stability, easy preparation and low-cost production make them versatile nanocarriers for the delivery of drugs and bioactive compounds by several routes including oral, ocular, topical, pulmonary, parenteral, and transmucosal [ 135 , 136 , 137 ].…”

Section: Brief Overview Of Nano-encapsulated Polyphenols: Nature and Physiochemical Polymer Benefitsmentioning

confidence: 99%

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

et al. 2021

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Polyphenols play a therapeutic role in vascular diseases, acting in inherent illness-associate conditions such as inflammation, diabetes, dyslipidemia, hypertension, and oxidative stress, as demonstrated by clinical trials and epidemiological surveys. The main polyphenol cardioprotective mechanisms rely on increased nitric oxide, decreased asymmetric dimethylarginine levels, upregulation of genes encoding antioxidant enzymes via the Nrf2-ARE pathway and anti-inflammatory action through the redox-sensitive transcription factor NF-κB and PPAR-γ receptor. However, poor polyphenol bioavailability and extensive metabolization restrict their applicability. Polyphenols carried by nanoparticles circumvent these limitations providing controlled release and better solubility, chemical protection, and target achievement. Nano-encapsulate polyphenols loaded in food grade polymers and lipids appear to be safe, gaining resistance in the enteric route for intestinal absorption, in which the mucoadhesiveness ensures their increased uptake, achieving high systemic levels in non-metabolized forms. Nano-capsules confer a gradual release to these compounds, as well as longer half-lives and cell and whole organism permanence, reinforcing their effectiveness, as demonstrated in pre-clinical trials, enabling their application as an adjuvant therapy against cardiovascular diseases. Polyphenol entrapment in nanoparticles should be encouraged in nutraceutical manufacturing for the fortification of foods and beverages. This study discusses pre-clinical trials evaluating how nano-encapsulate polyphenols following oral administration can aid in cardiovascular performance.

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A novel niosome formulation for encapsulation of anthocyanins and modelling intestinal transport

Cited by 51 publications

References 39 publications

Role of the Encapsulation in Bioavailability of Phenolic Compounds

Role of the Encapsulation in Bioavailability of Phenolic Compounds

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases

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