A Novel Natural Product for Bone Regeneration in Dentistry - A Review

Jain, Mokshi R.; M.S, Nivedhitha; Deepak, Sharma; Kumar, Santosh

doi:10.14260/jemds/2020/617

Cited by 3 publications

(5 citation statements)

References 21 publications

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“… Antioxidant qualities: Cissus extract is a rich source of several antioxidants that can combat oxidative stress, a major factor in the development of oral cancer. [ 1 ] Effects on inflammation: Precancerous oral lesions grow and advance in a manner that is strongly correlated with chronic inflammation. The probability of malignant transformation may be decreased by using Cissus extract to control inflammation.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The probability of malignant transformation may be decreased by using Cissus extract to control inflammation. [ 1 ] Cellular apoptosis: According to certain research, Cissus extract may cause malignant and precancerous cells to undergo apoptosis (programmed cell death), potentially halting the growth of oral diseases. In a study, the biological effects of CQ ethanolic extract on the KB oral epidermoid carcinoma cell line were assessed in vitro and validated by in silico analysis.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Antioxidant qualities: Cissus extract is a rich source of several antioxidants that can combat oxidative stress, a major factor in the development of oral cancer. [ 1 ]…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The probability of malignant transformation may be decreased by using Cissus extract to control inflammation. [ 1 ]…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The potential uses of Cissus extracts in enhancing oral health and treating dental problems have come under increased scrutiny in recent years. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

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Cissus Extracts in Dentistry: A Comprehensive Review on its Untapped Potential

Shinkre,

Rodrigues,

Mukherji

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Natural products have received a lot of attention in a variety of medical sectors, including dentistry. Cissus, a flowering plant genus, has long been used for its therapeutic benefits. The purpose of this review is to thoroughly investigate the possibilities of Cissus extracts in dentistry. To that end, we used specific selection criteria for the selection of pertinent scientific articles published in the scientific information databases of PubMed, Web of Science, Google Scholar, Scopus, and ProQuest. We found that the diverse array of bioactive compounds found in varied species of Cissus holds promise for applications ranging from oral wound healing to periodontal health. This review summarizes known studies on antibacterial, anti-inflammatory, and tissue-regenerative characteristics of Cissus extracts, shedding light on their potential significance in modernizing modern dental practices. It exerts that Cissus extracts have the potential to supplement established dentistry therapies by providing all-natural remedies for a variety of oral health conditions.

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Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Antioxidant qualities: Cissus extract is a rich source of several antioxidants that can combat oxidative stress, a major factor in the development of oral cancer. [ 1 ]…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The probability of malignant transformation may be decreased by using Cissus extract to control inflammation. [ 1 ]…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…The potential uses of Cissus extracts in enhancing oral health and treating dental problems have come under increased scrutiny in recent years. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cissus Extracts in Dentistry: A Comprehensive Review on its Untapped Potential

Shinkre,

Rodrigues,

Mukherji

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Phytochemical and Pharmacological Aspects of Cissus quadrangularis in Ayurveda

Meenakshi¹,

Akhtar²,

Khan³

2022

Chemistry, Biological Activities and Therapeutic Applications of Medicinal Plants in Ayurveda

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Cissus quadrangularis L. (family: Vitaceae) is an indigenous medicinal plant of India. It is used to treat several acute and chronic ailments, including bone-related disorders in Ayurveda. This chapter documents various bioactive metabolites isolated from C. quadrangularis. A detailed account of its in vitro and in vivo pharmacological activities, along with plausible mechanisms have been covered in this review. Few clinical studies have been conducted to evaluate its role in bone diseases and in weight loss. Light has been shed on its application and patents which have been granted to help the scientific community to explore the future therapeutic and scientific potential of this plant. Data from several acute and sub-chronic animal studies indicate that daily use of C. quadrangularis stem powder or extract for 90 days does not produce any unwanted side effects. However, there is a scarcity of data on their long-term clinical use in humans. Further preclinical investigations depicting the deep molecular pathways, potential, and mechanistic insights of phytoconstituents are warranted for in-depth scientific knowledge about this pharmaceutically important medicinal plant. Also, more randomized clinical trials are needed to establish the safety and efficacy of this miraculous Ayurvedic medicine in the management and treatment of various ailments.

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Phytochemicals in Periodontal Bone Regeneration

Manickam Natarajan,

Abdullah Jaber,

MDS

et al. 2024

RJPT

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Major regenerative therapies for periodontium are guided tissue regeneration (GTR) and bone grafting. Grafting the bone with hydroxyapatite is the current standard of care. Phytochemicals possess biological activity in animal physiological systems that offers affordable standard of care to the patients. In this context, osteogenic phytochemicals are reported in the literature. However, there is a lacuna in the literature in comparative efficacy of these phytochemicals. In this review three phytochemicals are compared – viz.β-sitosterol, Genistein and Emodin. Having proven by the previous investigators that β-sitosterol, Genitein and Emodin have effective osteogenic action when applied locally, it would be prudent to analyse the synergistic action for better osteogenesis. In principle, synergistic action is advantageous for both intensity and duration of action. As these molecules act at cellular level and have action on wide range of cells, it is necessary to deliver them locally with a proper scaffold or instrument. Effective combinations of these molecules can be incorporated with periodontal regenerative materials (GTR) to shift the balance towards regeneration of periodontium.

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A Novel Natural Product for Bone Regeneration in Dentistry - A Review

Cited by 3 publications

References 21 publications

Cissus Extracts in Dentistry: A Comprehensive Review on its Untapped Potential

Cissus Extracts in Dentistry: A Comprehensive Review on its Untapped Potential

Phytochemical and Pharmacological Aspects of Cissus quadrangularis in Ayurveda

Phytochemicals in Periodontal Bone Regeneration

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