A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis

Abstract

The naphthotriazolyl-4-oxoquinoline derivatives were obtained in good to moderate yields, and one of them, 12c, exhibited strong and selective antitumor properties. The antitumor mechanism involves inhibition of glycolysis, diminished intracellular ATP levels, induction of ROS production and triggering of apoptosis. These effects are all selective for cancer cells, since noncancer cells are unaffected, and these effects can only be attributed to the whole molecule, as different pharmacophoric groups did not reproduce these effects.

Isoquinolines alkaloids and cancer metabolism: Pathways and targets to novel chemotherapy

“…Some data from our group have demonstrated that hybrid compounds derived from quinones also have anticancer activity, and it was seen that these compounds interfere in cell metabolism of breast cancer cells by decreasing glucose consumption, lactate production, and ATP intracellular levels. Moreover, these compounds increased ROS production, as a consequence of mitochondrial membrane depolarization (Bortolot et al, 2019; Branco et al, 2018).…”