A novel nanocomposite based on covalent organic polymer and nanocellulose for thin‐film microextraction of imipramine from biological samples

Abstract

A novel covalent organic polymer was prepared using 1,5‐diaminonaphthalene as a linker and cyanuric chloride as a node. A thin‐film nanocomposite of 1,5‐diaminonaphthalene covalent organic polymer and cellulose nanocrystalline was then fabricated via filtering and casting method. The effect of incorporation of various amounts of 1,5‐diaminonaphthalene covalent organic polymer and cellulose nanocrystalline was studied to obtain an efficient nanocomposite thin‐film with a large number of polar functional groups and high mechanical stability. Field emission scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectrometry, and thermogravimetric analysis techniques were applied for the characterization of physicochemical properties of the prepared materials. Imipramine was determined in the biological samples using thin‐film microextraction followed by gas chromatography flame ionization detection. Parameters affecting the extraction efficiency of imipramine were investigated. Under the optimized conditions, the limit of detection was 0.5 ng/mL. Film‐to‐film reproducibility for three different films fabricated under the same conditions (at three concentration levels) varied between 8.9 and 9.7%. The linear dynamic range covered more than three orders of magnitude (2–5000 ng/mL) with a determination coefficient of 0.9985. The method was successfully applied for preconcentration and determination of imipramine in biological samples with spiking recoveries between 78 and 93%.

Development of a polyurethane‐coated thin film solid phase microextraction device for multi‐residue monitoring of pesticides in fruit and tea beverages

“…This ascertained that the determination of the analytes performed by the proposed method would not be affected significantly by the components in fruit juice and tea matrices. The extraction recovery and PF were evaluated by analyzing the 13 analytes at a concentration of 100.0 μg/L in pure water and were described as follows [35, 36]: $$$$\begin{equation}PF = \frac{{{C_f}}}{{{C_s}}}\end{equation}$$$$ $$$$\begin{equation}ER(\% ) = \frac{{{C_{\rm{f}}}}}{{{C_s}}} \times \frac{{{V_f}}}{{{V_s}}} \times 100\end{equation}$$$$where C f and C s are the analyte concentration in the final dissolved solution and the initial concentration of the analyte in the sample solution, respectively. V f and V s are the volumes of the final dissolved solution and sample solution, respectively.…”

“…This ascertained that the determination of the analytes performed by the proposed method would not be affected significantly by the components in fruit juice and tea matrices. The extraction recovery and PF were evaluated by analyzing the 13 analytes at a concentration of 100.0 μg/L in pure water and were described as follows [35,36]:…”

Smart sampling as the “Spot‐on” Method for LC‐MS protein analysis from dried blood spots

“…The information gathered in this article shows the potential of paper (cellulose) in sample preparation in a great variety of applications in all kinds of chemical analysis. The cellulose was modified with affinity materials such as molecularly imprinted polymers (MIPs) [8] or aptamers [9], or coated with covalent organic polymers [10]. Sample preparation of codeine and imipramine was performed using cellulose attached to a cotter pin placed in a liquid biosample.…”

Dual signal magnification for ultrasensitive biosensing based on well-regulated SERS of AuNTs@AuHg and DSN-assisted amplification

“…The characteristic peaks at 2850 cm À1 and 2917 cm À1 were attributed to the symmetric and asymmetric stretching vibration peaks of C-H stretching (Fig. 2b), 27 which stated that AuNTs were surrounded by the surfactant layer. The results with different Hg 2+ concentrations for the same moles of AuNTs displayed that AuHg alloy could replace the surfactant successfully to form AuNTs@AuHg as a Raman substrate.…”